In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Abstract The prognosis of lung metastatic osteosarcoma (OS) remains disappointing. siRNA-based gene silencing of VEGFR2 is a promising treatment strategy for lung metastatic OS, but there is a lack of safe and efficient delivery systems to encapsulate siRNAs for in vivo administration. This study pr...
| Auteurs principaux: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Publishing Group
2023-09-01
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| Collection: | Cell Death and Disease |
| Accès en ligne: | https://doi.org/10.1038/s41419-023-06159-3 |