Haemodialysis session: The perfect storm for vascular calcification
Introduction: Vascular calcification (VC) associated to chronic kidney disease (CKD) is a complex phenomenon closely related to mineral bone metabolism disorders. Many are the factors implicated, as the drugs used in the treatment of CKD. Some in vitro studies suggest that electrolyte and acid–base...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Nefrología (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S201325141500070X |
| _version_ | 1818140779544051712 |
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| author | Miguel Seras Ángel Luis Martín de Francisco Celestino Piñera Simón Gundin Marta García-Unzueta Maria Kislikova Zoila Albines Mara Serrano Manuel Arias |
| author_facet | Miguel Seras Ángel Luis Martín de Francisco Celestino Piñera Simón Gundin Marta García-Unzueta Maria Kislikova Zoila Albines Mara Serrano Manuel Arias |
| author_sort | Miguel Seras |
| collection | DOAJ |
| description | Introduction: Vascular calcification (VC) associated to chronic kidney disease (CKD) is a complex phenomenon closely related to mineral bone metabolism disorders. Many are the factors implicated, as the drugs used in the treatment of CKD. Some in vitro studies suggest that electrolyte and acid–base disorders induced by haemodialysis (HD) may play a key role in VC.
Methods: We analysed electrolyte and acid–base disorders that occur during an HD session in 26 patients randomly assigned to 1.25 mM or 1.5 mM calcium bath.
Results: There is a calcium load in all the patients, independently of calcium bath concentration or basal serum calcium levels. At the end of the session, 100% of the patients dialysed with 1.5 mM calcium bath have calcium serum levels >1.3 mM. However, this only occurs in 15% of the patients dialysed with 1.25 mM calcium bath. During this calcium load, phosphorus levels persist uncontrolled. Besides, there is a progressive alkalinisation in all the patients. In the end of the session 50% have serum bicarbonate >30 mM and 23% pH >7.5.
Conclusions: During HD sessions occur electrolyte and acid–base disorders that induce VC: calcium load and alkalisation in presence of elevated phosphorus levels. It is necessary to perform studies with kinetic models of calcium load and alkalinisation different from the actual ones. |
| first_indexed | 2024-12-11T10:49:25Z |
| format | Article |
| id | doaj.art-a0b65506317b4196be01c20c90c65689 |
| institution | Directory Open Access Journal |
| issn | 2013-2514 |
| language | English |
| last_indexed | 2024-12-11T10:49:25Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nefrología (English Edition) |
| spelling | doaj.art-a0b65506317b4196be01c20c90c656892022-12-22T01:10:22ZengElsevierNefrología (English Edition)2013-25142015-09-0135544845610.1016/j.nefroe.2015.09.008Haemodialysis session: The perfect storm for vascular calcificationMiguel Seras0Ángel Luis Martín de Francisco1Celestino Piñera2Simón Gundin3Marta García-Unzueta4Maria Kislikova5Zoila Albines6Mara Serrano7Manuel Arias8Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Análisis Clínicos, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Análisis Clínicos, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, SpainIntroduction: Vascular calcification (VC) associated to chronic kidney disease (CKD) is a complex phenomenon closely related to mineral bone metabolism disorders. Many are the factors implicated, as the drugs used in the treatment of CKD. Some in vitro studies suggest that electrolyte and acid–base disorders induced by haemodialysis (HD) may play a key role in VC. Methods: We analysed electrolyte and acid–base disorders that occur during an HD session in 26 patients randomly assigned to 1.25 mM or 1.5 mM calcium bath. Results: There is a calcium load in all the patients, independently of calcium bath concentration or basal serum calcium levels. At the end of the session, 100% of the patients dialysed with 1.5 mM calcium bath have calcium serum levels >1.3 mM. However, this only occurs in 15% of the patients dialysed with 1.25 mM calcium bath. During this calcium load, phosphorus levels persist uncontrolled. Besides, there is a progressive alkalinisation in all the patients. In the end of the session 50% have serum bicarbonate >30 mM and 23% pH >7.5. Conclusions: During HD sessions occur electrolyte and acid–base disorders that induce VC: calcium load and alkalisation in presence of elevated phosphorus levels. It is necessary to perform studies with kinetic models of calcium load and alkalinisation different from the actual ones.http://www.sciencedirect.com/science/article/pii/S201325141500070XVascular calcificationChronic kidney diseaseHaemodialysis |
| spellingShingle | Miguel Seras Ángel Luis Martín de Francisco Celestino Piñera Simón Gundin Marta García-Unzueta Maria Kislikova Zoila Albines Mara Serrano Manuel Arias Haemodialysis session: The perfect storm for vascular calcification Nefrología (English Edition) Vascular calcification Chronic kidney disease Haemodialysis |
| title | Haemodialysis session: The perfect storm for vascular calcification |
| title_full | Haemodialysis session: The perfect storm for vascular calcification |
| title_fullStr | Haemodialysis session: The perfect storm for vascular calcification |
| title_full_unstemmed | Haemodialysis session: The perfect storm for vascular calcification |
| title_short | Haemodialysis session: The perfect storm for vascular calcification |
| title_sort | haemodialysis session the perfect storm for vascular calcification |
| topic | Vascular calcification Chronic kidney disease Haemodialysis |
| url | http://www.sciencedirect.com/science/article/pii/S201325141500070X |
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