Test–retest reliability of the Friedreich’s ataxia rating scale
Abstract The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam‐based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-09-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51118 |
| _version_ | 1819087520639483904 |
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| author | Christian Rummey Theresa A. Zesiewicz Santiago Perez‐Lloret Jennifer M. Farmer Massimo Pandolfo David R. Lynch |
| author_facet | Christian Rummey Theresa A. Zesiewicz Santiago Perez‐Lloret Jennifer M. Farmer Massimo Pandolfo David R. Lynch |
| author_sort | Christian Rummey |
| collection | DOAJ |
| description | Abstract The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam‐based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore. |
| first_indexed | 2024-12-21T21:37:27Z |
| format | Article |
| id | doaj.art-a0b6ae74147544edba099c849dee977f |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-21T21:37:27Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-a0b6ae74147544edba099c849dee977f2022-12-21T18:49:26ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-09-01791708171210.1002/acn3.51118Test–retest reliability of the Friedreich’s ataxia rating scaleChristian Rummey0Theresa A. Zesiewicz1Santiago Perez‐Lloret2Jennifer M. Farmer3Massimo Pandolfo4David R. Lynch5Clinical Data Science GmbH Basel SwitzerlandUniversity of South Florida Ataxia Research Center Tampa FloridaInstitute of Cardiological Research University of Buenos Aires National Research Council (ININCA‐UBA‐CONICET) Marcelo T. de Alvear 2270 Buenos Aires C1122 ArgentinaFriedreich’s Ataxia Research Alliance Downingtown PennsylvaniaHôpital Erasme Université Libre de Bruxelles Brussels BelgiumChildren’s Hospital of Philadelphia Philadelphia PennsylvaniaAbstract The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam‐based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.https://doi.org/10.1002/acn3.51118 |
| spellingShingle | Christian Rummey Theresa A. Zesiewicz Santiago Perez‐Lloret Jennifer M. Farmer Massimo Pandolfo David R. Lynch Test–retest reliability of the Friedreich’s ataxia rating scale Annals of Clinical and Translational Neurology |
| title | Test–retest reliability of the Friedreich’s ataxia rating scale |
| title_full | Test–retest reliability of the Friedreich’s ataxia rating scale |
| title_fullStr | Test–retest reliability of the Friedreich’s ataxia rating scale |
| title_full_unstemmed | Test–retest reliability of the Friedreich’s ataxia rating scale |
| title_short | Test–retest reliability of the Friedreich’s ataxia rating scale |
| title_sort | test retest reliability of the friedreich s ataxia rating scale |
| url | https://doi.org/10.1002/acn3.51118 |
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