Glia-Neurons Cross-Talk Regulated Through Autophagy
Autophagy is a self-degradative process which plays a role in removing misfolded or aggregated proteins, clearing damaged organelles, but also in changes of cell membrane size and shape. The aim of this phenomenon is to deliver cytoplasmic cargo to the lysosome through the intermediary of a double m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.886273/full |
| _version_ | 1818009623823646720 |
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| author | Milena Damulewicz Kornel Szypulski Elzbieta Pyza |
| author_facet | Milena Damulewicz Kornel Szypulski Elzbieta Pyza |
| author_sort | Milena Damulewicz |
| collection | DOAJ |
| description | Autophagy is a self-degradative process which plays a role in removing misfolded or aggregated proteins, clearing damaged organelles, but also in changes of cell membrane size and shape. The aim of this phenomenon is to deliver cytoplasmic cargo to the lysosome through the intermediary of a double membrane-bound vesicle (autophagosome), that fuses with a lysosome to form autolysosome, where cargo is degraded by proteases. Products of degradation are transported back to the cytoplasm, where they can be re-used. In the present study we showed that autophagy is important for proper functioning of the glia and that it is involved in the regulation of circadian structural changes in processes of the pacemaker neurons. This effect is mainly observed in astrocyte-like glia, which play a role of peripheral circadian oscillators in the Drosophila brain. |
| first_indexed | 2024-04-14T05:44:06Z |
| format | Article |
| id | doaj.art-a0b76b1a773b422fbfd9ae64cb4bb2c3 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T05:44:06Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a0b76b1a773b422fbfd9ae64cb4bb2c32022-12-22T02:09:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-04-011310.3389/fphys.2022.886273886273Glia-Neurons Cross-Talk Regulated Through AutophagyMilena DamulewiczKornel SzypulskiElzbieta PyzaAutophagy is a self-degradative process which plays a role in removing misfolded or aggregated proteins, clearing damaged organelles, but also in changes of cell membrane size and shape. The aim of this phenomenon is to deliver cytoplasmic cargo to the lysosome through the intermediary of a double membrane-bound vesicle (autophagosome), that fuses with a lysosome to form autolysosome, where cargo is degraded by proteases. Products of degradation are transported back to the cytoplasm, where they can be re-used. In the present study we showed that autophagy is important for proper functioning of the glia and that it is involved in the regulation of circadian structural changes in processes of the pacemaker neurons. This effect is mainly observed in astrocyte-like glia, which play a role of peripheral circadian oscillators in the Drosophila brain.https://www.frontiersin.org/articles/10.3389/fphys.2022.886273/fullneuronal plasticitycircadian clocksleepDrosophilaautophagy |
| spellingShingle | Milena Damulewicz Kornel Szypulski Elzbieta Pyza Glia-Neurons Cross-Talk Regulated Through Autophagy Frontiers in Physiology neuronal plasticity circadian clock sleep Drosophila autophagy |
| title | Glia-Neurons Cross-Talk Regulated Through Autophagy |
| title_full | Glia-Neurons Cross-Talk Regulated Through Autophagy |
| title_fullStr | Glia-Neurons Cross-Talk Regulated Through Autophagy |
| title_full_unstemmed | Glia-Neurons Cross-Talk Regulated Through Autophagy |
| title_short | Glia-Neurons Cross-Talk Regulated Through Autophagy |
| title_sort | glia neurons cross talk regulated through autophagy |
| topic | neuronal plasticity circadian clock sleep Drosophila autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.886273/full |
| work_keys_str_mv | AT milenadamulewicz glianeuronscrosstalkregulatedthroughautophagy AT kornelszypulski glianeuronscrosstalkregulatedthroughautophagy AT elzbietapyza glianeuronscrosstalkregulatedthroughautophagy |