Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer
Ovarian cancer is the deadliest gynecological malignancy with a high prevalence of transcoelomic metastasis. Metastasis is a multi-step process and only a small percentage of cancer cells, metastasis-initiating cells (MICs), have the capacity to finally establish metastatic lesions. These MICs maint...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/12/1492 |
| _version_ | 1797381978728693760 |
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| author | Ji Wang James C. Ford Anirban K. Mitra |
| author_facet | Ji Wang James C. Ford Anirban K. Mitra |
| author_sort | Ji Wang |
| collection | DOAJ |
| description | Ovarian cancer is the deadliest gynecological malignancy with a high prevalence of transcoelomic metastasis. Metastasis is a multi-step process and only a small percentage of cancer cells, metastasis-initiating cells (MICs), have the capacity to finally establish metastatic lesions. These MICs maintain a certain level of stemness that allows them to differentiate into other cell types with distinct transcriptomic profiles and swiftly adapt to external stresses. Furthermore, they can coordinate with the microenvironment, through reciprocal interactions, to invade and establish metastases. Therefore, identifying, characterizing, and targeting MICs is a promising strategy to counter the spread of ovarian cancer. In this review, we provided an overview of OC MICs in the context of characterization, identification through cell surface markers, and their interactions with the metastatic niche to promote metastatic colonization. |
| first_indexed | 2024-03-08T20:58:51Z |
| format | Article |
| id | doaj.art-a0b7abb0e06647d1999a73040c084680 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-08T20:58:51Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a0b7abb0e06647d1999a73040c0846802023-12-22T13:54:25ZengMDPI AGBiology2079-77372023-12-011212149210.3390/biology12121492Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian CancerJi Wang0James C. Ford1Anirban K. Mitra2Indiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN 47405, USAIndiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN 47405, USAIndiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN 47405, USAOvarian cancer is the deadliest gynecological malignancy with a high prevalence of transcoelomic metastasis. Metastasis is a multi-step process and only a small percentage of cancer cells, metastasis-initiating cells (MICs), have the capacity to finally establish metastatic lesions. These MICs maintain a certain level of stemness that allows them to differentiate into other cell types with distinct transcriptomic profiles and swiftly adapt to external stresses. Furthermore, they can coordinate with the microenvironment, through reciprocal interactions, to invade and establish metastases. Therefore, identifying, characterizing, and targeting MICs is a promising strategy to counter the spread of ovarian cancer. In this review, we provided an overview of OC MICs in the context of characterization, identification through cell surface markers, and their interactions with the metastatic niche to promote metastatic colonization.https://www.mdpi.com/2079-7737/12/12/1492ovarian cancermetastasismetastasis-initiating cellsmicroenvironment |
| spellingShingle | Ji Wang James C. Ford Anirban K. Mitra Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer Biology ovarian cancer metastasis metastasis-initiating cells microenvironment |
| title | Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer |
| title_full | Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer |
| title_fullStr | Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer |
| title_full_unstemmed | Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer |
| title_short | Defining the Role of Metastasis-Initiating Cells in Promoting Carcinogenesis in Ovarian Cancer |
| title_sort | defining the role of metastasis initiating cells in promoting carcinogenesis in ovarian cancer |
| topic | ovarian cancer metastasis metastasis-initiating cells microenvironment |
| url | https://www.mdpi.com/2079-7737/12/12/1492 |
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