Bile Acids and Biliary Fibrosis
Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/5/792 |
| _version_ | 1797615599574056960 |
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| author | Sayed Obaidullah Aseem Phillip B. Hylemon Huiping Zhou |
| author_facet | Sayed Obaidullah Aseem Phillip B. Hylemon Huiping Zhou |
| author_sort | Sayed Obaidullah Aseem |
| collection | DOAJ |
| description | Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blood. Cholestasis may worsen with biliary fibrosis. Furthermore, bile acid levels, composition and homeostasis are dysregulated in PBC and PSC. In fact, mounting data from animal models and human cholangiopathies suggest that bile acids play a crucial role in the pathogenesis and progression of biliary fibrosis. The identification of bile acid receptors has advanced our understanding of various signaling pathways involved in regulating cholangiocyte functions and the potential impact on biliary fibrosis. We will also briefly review recent findings linking these receptors with epigenetic regulatory mechanisms. Further detailed understanding of bile acid signaling in the pathogenesis of biliary fibrosis will uncover additional therapeutic avenues for cholangiopathies. |
| first_indexed | 2024-03-11T07:28:58Z |
| format | Article |
| id | doaj.art-a0b7f108441c41eaa437150539ce9833 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T07:28:58Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a0b7f108441c41eaa437150539ce98332023-11-17T07:28:12ZengMDPI AGCells2073-44092023-03-0112579210.3390/cells12050792Bile Acids and Biliary FibrosisSayed Obaidullah Aseem0Phillip B. Hylemon1Huiping Zhou2Stravitz-Sanyal Institute for Liver Disease & Metabolic Health, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USABiliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blood. Cholestasis may worsen with biliary fibrosis. Furthermore, bile acid levels, composition and homeostasis are dysregulated in PBC and PSC. In fact, mounting data from animal models and human cholangiopathies suggest that bile acids play a crucial role in the pathogenesis and progression of biliary fibrosis. The identification of bile acid receptors has advanced our understanding of various signaling pathways involved in regulating cholangiocyte functions and the potential impact on biliary fibrosis. We will also briefly review recent findings linking these receptors with epigenetic regulatory mechanisms. Further detailed understanding of bile acid signaling in the pathogenesis of biliary fibrosis will uncover additional therapeutic avenues for cholangiopathies.https://www.mdpi.com/2073-4409/12/5/792biliary fibrosisbile acidsbile acid receptorscholangiocytescholangiopathies |
| spellingShingle | Sayed Obaidullah Aseem Phillip B. Hylemon Huiping Zhou Bile Acids and Biliary Fibrosis Cells biliary fibrosis bile acids bile acid receptors cholangiocytes cholangiopathies |
| title | Bile Acids and Biliary Fibrosis |
| title_full | Bile Acids and Biliary Fibrosis |
| title_fullStr | Bile Acids and Biliary Fibrosis |
| title_full_unstemmed | Bile Acids and Biliary Fibrosis |
| title_short | Bile Acids and Biliary Fibrosis |
| title_sort | bile acids and biliary fibrosis |
| topic | biliary fibrosis bile acids bile acid receptors cholangiocytes cholangiopathies |
| url | https://www.mdpi.com/2073-4409/12/5/792 |
| work_keys_str_mv | AT sayedobaidullahaseem bileacidsandbiliaryfibrosis AT phillipbhylemon bileacidsandbiliaryfibrosis AT huipingzhou bileacidsandbiliaryfibrosis |