Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia
Intrathecal chemoprophylaxis prevents central nervous system relapses in patients with acute lymphoblastic leukaemia (ALL) but few studies have addressed the predictive markers of relapse. Among these, traumatic lumbar puncture (TLP) has been associated with lower disease-free survival (DFS). To inv...
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| Format: | Article |
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2015-07-01
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| Series: | Revista Médica del Hospital General de México |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S018510631500044X |
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| author | G. Barranco-Lampón E. Rozen-Fuller I. Olarte-Carrilo A. Martínez-Tovar G. León-González H. Castellanos-Sinco A. Santoyo-Sánchez C.O. Ramos-Peñafiel J. Collazo-Jaloma |
| author_facet | G. Barranco-Lampón E. Rozen-Fuller I. Olarte-Carrilo A. Martínez-Tovar G. León-González H. Castellanos-Sinco A. Santoyo-Sánchez C.O. Ramos-Peñafiel J. Collazo-Jaloma |
| author_sort | G. Barranco-Lampón |
| collection | DOAJ |
| description | Intrathecal chemoprophylaxis prevents central nervous system relapses in patients with acute lymphoblastic leukaemia (ALL) but few studies have addressed the predictive markers of relapse. Among these, traumatic lumbar puncture (TLP) has been associated with lower disease-free survival (DFS).
To investigate the risk posed by TLP on relapse and DFS, we assembled a retrospective cohort including 79 patients with ALL who received intrathecal chemoprophylaxis during 2009 to 2013. One TLP per patient was recorded in 49 cases, and more than one TLP in 3. Mean follow-up was 283 (22–1118) days with an overall DFS of 68%. DFS was significantly lower in the group that had experienced TLP (58% vs 100% [P = .070]). Multiple TLP posed a greater risk of relapse than single TLP (P = .001). In conclusion, TLP in adults constitutes a major risk factor, greater than that reported in the large paediatric series. |
| first_indexed | 2024-12-21T22:47:29Z |
| format | Article |
| id | doaj.art-a0ba1ff4226445e986d8da6e95faf7e2 |
| institution | Directory Open Access Journal |
| issn | 0185-1063 |
| language | English |
| last_indexed | 2024-12-21T22:47:29Z |
| publishDate | 2015-07-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Médica del Hospital General de México |
| spelling | doaj.art-a0ba1ff4226445e986d8da6e95faf7e22022-12-21T18:47:40ZengPermanyerRevista Médica del Hospital General de México0185-10632015-07-0178312412810.1016/j.hgmx.2015.08.002Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemiaG. Barranco-Lampón0E. Rozen-Fuller1I. Olarte-Carrilo2A. Martínez-Tovar3G. León-González4H. Castellanos-Sinco5A. Santoyo-Sánchez6C.O. Ramos-Peñafiel7J. Collazo-Jaloma8Servicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoUnidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoServicio de Hematología, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoIntrathecal chemoprophylaxis prevents central nervous system relapses in patients with acute lymphoblastic leukaemia (ALL) but few studies have addressed the predictive markers of relapse. Among these, traumatic lumbar puncture (TLP) has been associated with lower disease-free survival (DFS). To investigate the risk posed by TLP on relapse and DFS, we assembled a retrospective cohort including 79 patients with ALL who received intrathecal chemoprophylaxis during 2009 to 2013. One TLP per patient was recorded in 49 cases, and more than one TLP in 3. Mean follow-up was 283 (22–1118) days with an overall DFS of 68%. DFS was significantly lower in the group that had experienced TLP (58% vs 100% [P = .070]). Multiple TLP posed a greater risk of relapse than single TLP (P = .001). In conclusion, TLP in adults constitutes a major risk factor, greater than that reported in the large paediatric series.http://www.sciencedirect.com/science/article/pii/S018510631500044XSpinal punctureDisease-free survivalLeukaemiaCentral nervous systemRecurrence |
| spellingShingle | G. Barranco-Lampón E. Rozen-Fuller I. Olarte-Carrilo A. Martínez-Tovar G. León-González H. Castellanos-Sinco A. Santoyo-Sánchez C.O. Ramos-Peñafiel J. Collazo-Jaloma Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia Revista Médica del Hospital General de México Spinal puncture Disease-free survival Leukaemia Central nervous system Recurrence |
| title | Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| title_full | Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| title_fullStr | Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| title_full_unstemmed | Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| title_short | Association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| title_sort | association between traumatic lumbar puncture and the risk of central nervous system relapse in adults with acute lymphoblastic leukaemia |
| topic | Spinal puncture Disease-free survival Leukaemia Central nervous system Recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S018510631500044X |
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