RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS
The purpose of the study was to review available literature on the efficacy of radiopharmaceuticals based on glucose derivatives labeled with radioactive isotopes for detection of various cancers. Material and methods. A systematic literature review was performed using the Scopus, Web of Science, Me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2018-05-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/718 |
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| author | R. V. Zeltchan A. A. Medvedeva I. G. Sinilkin O. V. Bragina V. J. Chernov |
| author_facet | R. V. Zeltchan A. A. Medvedeva I. G. Sinilkin O. V. Bragina V. J. Chernov |
| author_sort | R. V. Zeltchan |
| collection | DOAJ |
| description | The purpose of the study was to review available literature on the efficacy of radiopharmaceuticals based on glucose derivatives labeled with radioactive isotopes for detection of various cancers. Material and methods. A systematic literature review was performed using the Scopus, Web of Science, MedLine, Cochrane Library, EMBASE, and Global Health databases from 2000 to 2016. Out of 900 papers in the field of nuclear medicine, 58 were included into the review. Results. 18F-fluoro-2-deoxy-D-glucose (18F-FDG) has been approved to be a powerful imaging tool for the detection of various cancers as well as for the assessment of tumor extent and therapy response. There is a continuous search for new more specific and effective radiopharmaceuticals for visualization of tumor tissue. Many studies are devoted to the development of radiopharmaceuticals based on technetium-99m labeled glucose derivatives for tumor visualization. Russian researches have made a significant progress in the development of imaging agents for single-photon emission computed tomography. Conclusion. Despite the widespread use of positron emission tomography technologies, which have proved to be effective, the specialists still have a great interest in radiopharmaceuticals based on technetium-99m. The literature review suggests that the emergence of a diagnostic radiopharmaceutical based on technetium-99m labeled glucose derivative will help to improve the availability of nuclear medicine methods and their effectiveness. |
| first_indexed | 2024-04-10T01:53:31Z |
| format | Article |
| id | doaj.art-a0bae232e7a3489c90115cfc7972b859 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:08:46Z |
| publishDate | 2018-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-a0bae232e7a3489c90115cfc7972b8592025-03-02T11:16:10ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-05-01172718110.21294/1814-4861-2018-17-2-71-81532RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSISR. V. Zeltchan0A. A. Medvedeva1I. G. Sinilkin2O. V. Bragina3V. J. Chernov4Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk; National Research Tomsk Polytechnic University, TomskThe purpose of the study was to review available literature on the efficacy of radiopharmaceuticals based on glucose derivatives labeled with radioactive isotopes for detection of various cancers. Material and methods. A systematic literature review was performed using the Scopus, Web of Science, MedLine, Cochrane Library, EMBASE, and Global Health databases from 2000 to 2016. Out of 900 papers in the field of nuclear medicine, 58 were included into the review. Results. 18F-fluoro-2-deoxy-D-glucose (18F-FDG) has been approved to be a powerful imaging tool for the detection of various cancers as well as for the assessment of tumor extent and therapy response. There is a continuous search for new more specific and effective radiopharmaceuticals for visualization of tumor tissue. Many studies are devoted to the development of radiopharmaceuticals based on technetium-99m labeled glucose derivatives for tumor visualization. Russian researches have made a significant progress in the development of imaging agents for single-photon emission computed tomography. Conclusion. Despite the widespread use of positron emission tomography technologies, which have proved to be effective, the specialists still have a great interest in radiopharmaceuticals based on technetium-99m. The literature review suggests that the emergence of a diagnostic radiopharmaceutical based on technetium-99m labeled glucose derivative will help to improve the availability of nuclear medicine methods and their effectiveness.https://www.siboncoj.ru/jour/article/view/718radionuclide diagnosisradiopharmaceuticalsglucose derivativestechnetium-99mfluorodeoxyglucose |
| spellingShingle | R. V. Zeltchan A. A. Medvedeva I. G. Sinilkin O. V. Bragina V. J. Chernov RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS Сибирский онкологический журнал radionuclide diagnosis radiopharmaceuticals glucose derivatives technetium-99m fluorodeoxyglucose |
| title | RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS |
| title_full | RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS |
| title_fullStr | RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS |
| title_full_unstemmed | RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS |
| title_short | RADIOPHARMACEUTICALS BASED ON THE GLUCOSE DERIVATIVES FOR TUMOR DIAGNOSIS |
| title_sort | radiopharmaceuticals based on the glucose derivatives for tumor diagnosis |
| topic | radionuclide diagnosis radiopharmaceuticals glucose derivatives technetium-99m fluorodeoxyglucose |
| url | https://www.siboncoj.ru/jour/article/view/718 |
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