Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva
The development of accessible express methods to determine markers of viral diseases in saliva is currently an actual problem. Novel cross-sensitive sensors based on Donnan potential with bio-comparable perfluorosulfonic acid membranes for the determination of salivary viral markers (<i>N</...
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MDPI AG
2023-07-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/13/8/701 |
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| author | Anna V. Parshina Ekaterina Yu. Safronova Svetlana A. Novikova Nastasia Stretton Anastasia S. Yelnikova Timur R. Zhuchkov Olga V. Bobreshova Andrey B. Yaroslavtsev |
| author_facet | Anna V. Parshina Ekaterina Yu. Safronova Svetlana A. Novikova Nastasia Stretton Anastasia S. Yelnikova Timur R. Zhuchkov Olga V. Bobreshova Andrey B. Yaroslavtsev |
| author_sort | Anna V. Parshina |
| collection | DOAJ |
| description | The development of accessible express methods to determine markers of viral diseases in saliva is currently an actual problem. Novel cross-sensitive sensors based on Donnan potential with bio-comparable perfluorosulfonic acid membranes for the determination of salivary viral markers (<i>N</i>-acetyl-<i>L</i>-methionine, <i>L</i>-carnitine, and <i>L</i>-lysine) were proposed. Membranes were formed by casting from dispersions of Nafion or Aquivion in <i>N</i>-methyl-2-pyrollidone or in a mixture of isopropyl alcohol and water. The influence of the polymer equivalent weight and the nature of dispersing liquid on water uptake, ion conductivity, and slope of Donnan potential for the membranes in H<sup>+</sup> and Na<sup>+</sup> form was investigated. The varying of the sorption and transport properties of perfluorosulfonic acid membranes provided a change in the distribution of the sensor sensitivity to <i>N</i>-acetyl-<i>L</i>-methionine, <i>L</i>-carnitine, and <i>L</i>-lysine ions, which was necessary for multisensory system development. The simultaneous determination of three analytes, and the group analysis of them in artificial saliva solutions, was performed. The errors of <i>N</i>-acetyl-<i>L</i>-methionine and <i>L</i>-carnitine determination were 4–12 and 3–11%, respectively. The determination of <i>L</i>-lysine was complicated by its interaction with Ca<sup>2+</sup> ions. The error of the group analysis was no greater than 9%. The reverse character of the viral markers’ sorption by the membranes provided long-term sensor operation. |
| first_indexed | 2024-03-10T23:44:49Z |
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| id | doaj.art-a0bb1c30b1814b97abcf458e65d707ff |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T23:44:49Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Membranes |
| spelling | doaj.art-a0bb1c30b1814b97abcf458e65d707ff2023-11-19T02:07:36ZengMDPI AGMembranes2077-03752023-07-0113870110.3390/membranes13080701Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in SalivaAnna V. Parshina0Ekaterina Yu. Safronova1Svetlana A. Novikova2Nastasia Stretton3Anastasia S. Yelnikova4Timur R. Zhuchkov5Olga V. Bobreshova6Andrey B. Yaroslavtsev7Department of Analytical Chemistry, Voronezh State University, 394018 Voronezh, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, RussiaDepartment of Analytical Chemistry, Voronezh State University, 394018 Voronezh, RussiaDepartment of Analytical Chemistry, Voronezh State University, 394018 Voronezh, RussiaDepartment of Analytical Chemistry, Voronezh State University, 394018 Voronezh, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, RussiaThe development of accessible express methods to determine markers of viral diseases in saliva is currently an actual problem. Novel cross-sensitive sensors based on Donnan potential with bio-comparable perfluorosulfonic acid membranes for the determination of salivary viral markers (<i>N</i>-acetyl-<i>L</i>-methionine, <i>L</i>-carnitine, and <i>L</i>-lysine) were proposed. Membranes were formed by casting from dispersions of Nafion or Aquivion in <i>N</i>-methyl-2-pyrollidone or in a mixture of isopropyl alcohol and water. The influence of the polymer equivalent weight and the nature of dispersing liquid on water uptake, ion conductivity, and slope of Donnan potential for the membranes in H<sup>+</sup> and Na<sup>+</sup> form was investigated. The varying of the sorption and transport properties of perfluorosulfonic acid membranes provided a change in the distribution of the sensor sensitivity to <i>N</i>-acetyl-<i>L</i>-methionine, <i>L</i>-carnitine, and <i>L</i>-lysine ions, which was necessary for multisensory system development. The simultaneous determination of three analytes, and the group analysis of them in artificial saliva solutions, was performed. The errors of <i>N</i>-acetyl-<i>L</i>-methionine and <i>L</i>-carnitine determination were 4–12 and 3–11%, respectively. The determination of <i>L</i>-lysine was complicated by its interaction with Ca<sup>2+</sup> ions. The error of the group analysis was no greater than 9%. The reverse character of the viral markers’ sorption by the membranes provided long-term sensor operation.https://www.mdpi.com/2077-0375/13/8/701PFSA membraneNafionAquivionion transportDonnan potentialpotentiometric multisensory system |
| spellingShingle | Anna V. Parshina Ekaterina Yu. Safronova Svetlana A. Novikova Nastasia Stretton Anastasia S. Yelnikova Timur R. Zhuchkov Olga V. Bobreshova Andrey B. Yaroslavtsev Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva Membranes PFSA membrane Nafion Aquivion ion transport Donnan potential potentiometric multisensory system |
| title | Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva |
| title_full | Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva |
| title_fullStr | Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva |
| title_full_unstemmed | Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva |
| title_short | Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva |
| title_sort | perfluorosulfonic acid membranes with short and long side chains and their use in sensors for the determination of markers of viral diseases in saliva |
| topic | PFSA membrane Nafion Aquivion ion transport Donnan potential potentiometric multisensory system |
| url | https://www.mdpi.com/2077-0375/13/8/701 |
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