Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine
Bronchiectasis is a complex and heterogeneous disease, defining complexity as to the non-linear relationship between the different characteristics that make up the disease, and heterogeneous in the sense that not all these variables appear in the same patient. As a consequence of the complexity and...
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| Format: | Article |
| Language: | English |
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Publicaciones Permanyer
2022-01-01
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| Series: | Barcelona Respiratory Network Reviews |
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| Online Access: | https://www.brnreviews.com/frame_esp.php?id=208 |
| _version_ | 1797688472012587008 |
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| author | Grace Oscullo Alberto García-Ortega Jose D. Gómez-Olivas Thais Beauperthuy Amina Bekki Miguel A. Martinez-Garcia |
| author_facet | Grace Oscullo Alberto García-Ortega Jose D. Gómez-Olivas Thais Beauperthuy Amina Bekki Miguel A. Martinez-Garcia |
| author_sort | Grace Oscullo |
| collection | DOAJ |
| description | Bronchiectasis is a complex and heterogeneous disease, defining complexity as to the non-linear relationship between the different characteristics that make up the disease, and heterogeneous in the sense that not all these variables appear in the same patient. As a consequence of the complexity and heterogeneity of bronchiectasis, different clinical phenotypes can be established (mainly chronic bronchial infection by Pseudomonas aeruginosa, the exacerbator patient, and the overlap with chronic obstructive pulmonary disease [COPD]), as well as endotypes (basically neutrophilic and eosinophilic). Beyond phenotypes and endotypes, some authors have recently developed some tools to capture the multidimensional nature of bronchiectasis such as the control panel and clinical fingerprint. These tools are based on the concepts of severity, activity and impact of the disease. Finally, the concept of treatable trait, initially described in COPD patients and defined as those characteristics of bronchiectasis that are treatable (or potentially treatable) is discussed.
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| first_indexed | 2024-03-12T01:31:28Z |
| format | Article |
| id | doaj.art-a0bc1a20baaf4abf902c8be5b08c0925 |
| institution | Directory Open Access Journal |
| issn | 2462-3172 |
| language | English |
| last_indexed | 2024-03-12T01:31:28Z |
| publishDate | 2022-01-01 |
| publisher | Publicaciones Permanyer |
| record_format | Article |
| series | Barcelona Respiratory Network Reviews |
| spelling | doaj.art-a0bc1a20baaf4abf902c8be5b08c09252023-09-12T02:11:37ZengPublicaciones PermanyerBarcelona Respiratory Network Reviews2462-31722022-01-018110.23866/BRNRev:2021-0008Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized MedicineGrace Oscullo0Alberto García-Ortega1Jose D. Gómez-Olivas2Thais Beauperthuy3Amina Bekki4Miguel A. Martinez-Garcia5Servicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia, SpainServicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia, SpainServicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia, SpainServicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia, SpainServicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia, SpainServicio de Neumología, Hospital Universitario y Politécnico La Fe Valencia, Valencia Centro de Investigación Biomédica en Red de enfermedades respiratorias CIBERER), Instituto de Salud Carlos III, Madrid. SpainBronchiectasis is a complex and heterogeneous disease, defining complexity as to the non-linear relationship between the different characteristics that make up the disease, and heterogeneous in the sense that not all these variables appear in the same patient. As a consequence of the complexity and heterogeneity of bronchiectasis, different clinical phenotypes can be established (mainly chronic bronchial infection by Pseudomonas aeruginosa, the exacerbator patient, and the overlap with chronic obstructive pulmonary disease [COPD]), as well as endotypes (basically neutrophilic and eosinophilic). Beyond phenotypes and endotypes, some authors have recently developed some tools to capture the multidimensional nature of bronchiectasis such as the control panel and clinical fingerprint. These tools are based on the concepts of severity, activity and impact of the disease. Finally, the concept of treatable trait, initially described in COPD patients and defined as those characteristics of bronchiectasis that are treatable (or potentially treatable) is discussed. https://www.brnreviews.com/frame_esp.php?id=208Chronic obstructive pulmonary disease. Endotypes. Exacerbation. Precision medicine. Phenotypes. Treatable trait. |
| spellingShingle | Grace Oscullo Alberto García-Ortega Jose D. Gómez-Olivas Thais Beauperthuy Amina Bekki Miguel A. Martinez-Garcia Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine Barcelona Respiratory Network Reviews Chronic obstructive pulmonary disease. Endotypes. Exacerbation. Precision medicine. Phenotypes. Treatable trait. |
| title | Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine |
| title_full | Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine |
| title_fullStr | Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine |
| title_full_unstemmed | Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine |
| title_short | Complexity and Heterogeneity in Bronchiectasis: Towards a Personalized Medicine |
| title_sort | complexity and heterogeneity in bronchiectasis towards a personalized medicine |
| topic | Chronic obstructive pulmonary disease. Endotypes. Exacerbation. Precision medicine. Phenotypes. Treatable trait. |
| url | https://www.brnreviews.com/frame_esp.php?id=208 |
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