Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modific...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-10-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/1533033820964194 |
| _version_ | 1811297086931468288 |
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| author | Mujib Ullah MD, PhD Asma Akbar PhD Gustavo Yannarelli PhD |
| author_facet | Mujib Ullah MD, PhD Asma Akbar PhD Gustavo Yannarelli PhD |
| author_sort | Mujib Ullah MD, PhD |
| collection | DOAJ |
| description | Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer. |
| first_indexed | 2024-04-13T05:58:50Z |
| format | Article |
| id | doaj.art-a0bc2d3af37a4d10b943077117848f11 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-13T05:58:50Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-a0bc2d3af37a4d10b943077117848f112022-12-22T02:59:31ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-10-011910.1177/1533033820964194Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future DirectionsMujib Ullah MD, PhD0Asma Akbar PhD1Gustavo Yannarelli PhD2 Molecular Medicine, Department of Radiology, School of Medicine, , CA, USA Molecular Medicine, Department of Radiology, School of Medicine, , CA, USA Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, ArgentinaEarly detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer.https://doi.org/10.1177/1533033820964194 |
| spellingShingle | Mujib Ullah MD, PhD Asma Akbar PhD Gustavo Yannarelli PhD Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions Technology in Cancer Research & Treatment |
| title | Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions |
| title_full | Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions |
| title_fullStr | Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions |
| title_full_unstemmed | Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions |
| title_short | Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions |
| title_sort | clinical applications of rna editing technology for the early detection of cancer and future directions |
| url | https://doi.org/10.1177/1533033820964194 |
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