Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2017.00087/full |
| _version_ | 1828824562933956608 |
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| author | Marta Anna Kowalik Amedeo Columbano Andrea Perra |
| author_facet | Marta Anna Kowalik Amedeo Columbano Andrea Perra |
| author_sort | Marta Anna Kowalik |
| collection | DOAJ |
| description | In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC. |
| first_indexed | 2024-12-12T13:58:39Z |
| format | Article |
| id | doaj.art-a0bcc93043764f4689c5277cd4274c58 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T13:58:39Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a0bcc93043764f4689c5277cd4274c582022-12-22T00:22:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2017-05-01710.3389/fonc.2017.00087253842Emerging Role of the Pentose Phosphate Pathway in Hepatocellular CarcinomaMarta Anna Kowalik0Amedeo Columbano1Andrea Perra2Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, ItalyIn recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC.http://journal.frontiersin.org/article/10.3389/fonc.2017.00087/fullglucose-6-phosphate dehydrogenasemetabolic reprogrammingWarburg metabolismpentose phosphate pathwaypreneoplastic lesionshepatocellular carcinoma |
| spellingShingle | Marta Anna Kowalik Amedeo Columbano Andrea Perra Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma Frontiers in Oncology glucose-6-phosphate dehydrogenase metabolic reprogramming Warburg metabolism pentose phosphate pathway preneoplastic lesions hepatocellular carcinoma |
| title | Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma |
| title_full | Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma |
| title_fullStr | Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma |
| title_full_unstemmed | Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma |
| title_short | Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma |
| title_sort | emerging role of the pentose phosphate pathway in hepatocellular carcinoma |
| topic | glucose-6-phosphate dehydrogenase metabolic reprogramming Warburg metabolism pentose phosphate pathway preneoplastic lesions hepatocellular carcinoma |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2017.00087/full |
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