Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022.
High-income countries have documented a significant decline in the incidence and mortality of cervical cancer over the past decade but such data from low and middle-income countries such as Uganda is limited to ascertain trends. There is also paucity of data on the burden of cervical cancer in compa...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002848&type=printable |
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| author | Rogers Kajabwangu Francis Bajunirwe Jonathan Izudi Joel Bazira Yarine Farjardo Frank Ssedyabane Henry Mark Lugobe Joy Muhumuza Musa Kayondo Stuart Turanzomwe Thomas C Randall Joseph Ngonzi |
| author_facet | Rogers Kajabwangu Francis Bajunirwe Jonathan Izudi Joel Bazira Yarine Farjardo Frank Ssedyabane Henry Mark Lugobe Joy Muhumuza Musa Kayondo Stuart Turanzomwe Thomas C Randall Joseph Ngonzi |
| author_sort | Rogers Kajabwangu |
| collection | DOAJ |
| description | High-income countries have documented a significant decline in the incidence and mortality of cervical cancer over the past decade but such data from low and middle-income countries such as Uganda is limited to ascertain trends. There is also paucity of data on the burden of cervical cancer in comparison to other gynaecologic malignancies and there is a likelihood that the incidence might be on the rise. To describe the current trends and magnitude of cervical cancer in comparison to other gynaecological malignancies histological types, we conducted a retrospective records review of charts of patients admitted with gynaecological malignancies on the gynaecological ward of Mbarara Regional Referral Hospital (MRRH) between January 2017 and December 2022. Of 875 patients with gynaecological malignancies admitted to the MRRH in the 6-year review period, 721 (82.4%) had cervical cancer. Patients with cervical cancer were significantly older than those with other gynaecological malignancies: (50.2±11.5 versus 43.8± 15.0 respectively, p<0.001). Between 2017 and 2022, cervical cancer rates increased by 17% annually compared to other gynaecological cancers (OR:1.17; 95% CI 1.06-1.28, p = 0.0046), with the majority of patients of cervical cancer patients (92.7%, n = 668) having squamous cell carcinoma. Most patients (87.9%, n = 634) had late-stage disease (stage 2 and above) and were referred to the Uganda Cancer Institute for chemoradiation. These results imply that there is a need to scale up screening services and other preventive measures such as vaccination against human papilloma virus. |
| first_indexed | 2024-03-08T03:10:00Z |
| format | Article |
| id | doaj.art-a0bd90fc54db49e88824cb8ceff623a4 |
| institution | Directory Open Access Journal |
| issn | 2767-3375 |
| language | English |
| last_indexed | 2024-03-08T03:10:00Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj.art-a0bd90fc54db49e88824cb8ceff623a42024-02-13T06:00:13ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-0141e000284810.1371/journal.pgph.0002848Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022.Rogers KajabwanguFrancis BajunirweJonathan IzudiJoel BaziraYarine FarjardoFrank SsedyabaneHenry Mark LugobeJoy MuhumuzaMusa KayondoStuart TuranzomweThomas C RandallJoseph NgonziHigh-income countries have documented a significant decline in the incidence and mortality of cervical cancer over the past decade but such data from low and middle-income countries such as Uganda is limited to ascertain trends. There is also paucity of data on the burden of cervical cancer in comparison to other gynaecologic malignancies and there is a likelihood that the incidence might be on the rise. To describe the current trends and magnitude of cervical cancer in comparison to other gynaecological malignancies histological types, we conducted a retrospective records review of charts of patients admitted with gynaecological malignancies on the gynaecological ward of Mbarara Regional Referral Hospital (MRRH) between January 2017 and December 2022. Of 875 patients with gynaecological malignancies admitted to the MRRH in the 6-year review period, 721 (82.4%) had cervical cancer. Patients with cervical cancer were significantly older than those with other gynaecological malignancies: (50.2±11.5 versus 43.8± 15.0 respectively, p<0.001). Between 2017 and 2022, cervical cancer rates increased by 17% annually compared to other gynaecological cancers (OR:1.17; 95% CI 1.06-1.28, p = 0.0046), with the majority of patients of cervical cancer patients (92.7%, n = 668) having squamous cell carcinoma. Most patients (87.9%, n = 634) had late-stage disease (stage 2 and above) and were referred to the Uganda Cancer Institute for chemoradiation. These results imply that there is a need to scale up screening services and other preventive measures such as vaccination against human papilloma virus.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002848&type=printable |
| spellingShingle | Rogers Kajabwangu Francis Bajunirwe Jonathan Izudi Joel Bazira Yarine Farjardo Frank Ssedyabane Henry Mark Lugobe Joy Muhumuza Musa Kayondo Stuart Turanzomwe Thomas C Randall Joseph Ngonzi Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. PLOS Global Public Health |
| title | Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. |
| title_full | Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. |
| title_fullStr | Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. |
| title_full_unstemmed | Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. |
| title_short | Magnitude and trends in cervical cancer at Mbarara Regional Referral Hospital in South Western Uganda: Retrospective analysis of data from 2017-2022. |
| title_sort | magnitude and trends in cervical cancer at mbarara regional referral hospital in south western uganda retrospective analysis of data from 2017 2022 |
| url | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002848&type=printable |
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