A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs

A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs

The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to regulate gene expression. Enhancer RNAs (eRNAs) are subclass of lncRNAs that are synthesized fr...

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Bibliographic Details
Main Authors: Dinesh Babu Uthaya Kumar, Marina Yurieva, Jessica Grassmann, Lina Kozhaya, Caleb Dante McBride, Derya Unutmaz, Adam Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
CRISPR-screen
EMT
lncRNA
eRNA
SNAI1
CD44
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1110445/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1110445/full

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