Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice
Alzheimer’s disease (AD) is the most common form of dementia, and the cognitive impairments associated with this degenerative disease seriously affect daily life. Nutraceuticals for the prevention or delay of AD are urgently needed. It has been increasingly observed that phycocyanin (PC) exerts neur...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4431 |
| _version_ | 1797501788987850752 |
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| author | Yasuyuki Imai Yurino Koseki Makoto Hirano Shin Nakamura |
| author_facet | Yasuyuki Imai Yurino Koseki Makoto Hirano Shin Nakamura |
| author_sort | Yasuyuki Imai |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common form of dementia, and the cognitive impairments associated with this degenerative disease seriously affect daily life. Nutraceuticals for the prevention or delay of AD are urgently needed. It has been increasingly observed that phycocyanin (PC) exerts neuroprotective effects. AD model mice intracerebroventricularly injected with amyloid beta-peptide 25–35 (Aβ<sub>25–35</sub>) at 10 nmol/head displayed significant cognitive impairment in the spontaneous alternation test. Cognitive impairment was significantly ameliorated in mice treated with 750 mg/kg of enzyme-digested (ED) PC by daily oral administration for 22 consecutive days. Application of DNA microarray data on hippocampal gene expression to nutrigenomics studies revealed that oral EDPC counteracted the aberrant expression of 35 genes, including <i>Prnp</i>, <i>Cct4</i>, <i>Vegfd</i> (<i>Figf</i>), <i>Map9</i> (<i>Mtap9</i>), <i>Pik3cg</i>, <i>Zfand5</i>, <i>Endog</i>, and <i>Hbq1a</i>. These results suggest that oral administration of EDPC ameliorated cognitive impairment in AD model mice by maintaining and/or restoring normal gene expression patterns in the hippocampus. |
| first_indexed | 2024-03-10T03:23:36Z |
| format | Article |
| id | doaj.art-a0c0f9a48b704ff48b6d033d67802366 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:23:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a0c0f9a48b704ff48b6d033d678023662023-11-23T09:57:37ZengMDPI AGNutrients2072-66432021-12-011312443110.3390/nu13124431Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model MiceYasuyuki Imai0Yurino Koseki1Makoto Hirano2Shin Nakamura3Health Care Technical G., Chiba Plants, DIC Corporation, Ichihara 290-8585, Chiba, JapanHealth Care Technical G., Chiba Plants, DIC Corporation, Ichihara 290-8585, Chiba, JapanR&D Institute, Intelligence & Technology Lab, Inc., Kaizu 503-0628, Gifu, JapanR&D Institute, Intelligence & Technology Lab, Inc., Kaizu 503-0628, Gifu, JapanAlzheimer’s disease (AD) is the most common form of dementia, and the cognitive impairments associated with this degenerative disease seriously affect daily life. Nutraceuticals for the prevention or delay of AD are urgently needed. It has been increasingly observed that phycocyanin (PC) exerts neuroprotective effects. AD model mice intracerebroventricularly injected with amyloid beta-peptide 25–35 (Aβ<sub>25–35</sub>) at 10 nmol/head displayed significant cognitive impairment in the spontaneous alternation test. Cognitive impairment was significantly ameliorated in mice treated with 750 mg/kg of enzyme-digested (ED) PC by daily oral administration for 22 consecutive days. Application of DNA microarray data on hippocampal gene expression to nutrigenomics studies revealed that oral EDPC counteracted the aberrant expression of 35 genes, including <i>Prnp</i>, <i>Cct4</i>, <i>Vegfd</i> (<i>Figf</i>), <i>Map9</i> (<i>Mtap9</i>), <i>Pik3cg</i>, <i>Zfand5</i>, <i>Endog</i>, and <i>Hbq1a</i>. These results suggest that oral administration of EDPC ameliorated cognitive impairment in AD model mice by maintaining and/or restoring normal gene expression patterns in the hippocampus.https://www.mdpi.com/2072-6643/13/12/4431Y maze<i>Spirulina</i>Creutzfeldt–Jakob diseaseneurodegenerative diseasehippocampusamyloid β-peptide(<sub>25–35</sub>) |
| spellingShingle | Yasuyuki Imai Yurino Koseki Makoto Hirano Shin Nakamura Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice Nutrients Y maze <i>Spirulina</i> Creutzfeldt–Jakob disease neurodegenerative disease hippocampus amyloid β-peptide(<sub>25–35</sub>) |
| title | Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice |
| title_full | Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice |
| title_fullStr | Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice |
| title_full_unstemmed | Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice |
| title_short | Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice |
| title_sort | nutrigenomic studies on the ameliorative effect of enzyme digested phycocyanin in alzheimer s disease model mice |
| topic | Y maze <i>Spirulina</i> Creutzfeldt–Jakob disease neurodegenerative disease hippocampus amyloid β-peptide(<sub>25–35</sub>) |
| url | https://www.mdpi.com/2072-6643/13/12/4431 |
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