Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial
Background: To observe clinical effects of Shen Cao granules on thrombocytopenia in patients with gastrointestinal cancer undergoing chemotherapy. Patients and Methods: Patients under a FOLFIRI chemotherapy regimen (n = 92) were randomly divided into study and control groups (n = 46 for each group)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-02-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735419829568 |
| _version_ | 1818257931466964992 |
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| author | Chunfeng Yu MS Wei Liu MS Yuejun Mu MS Aihua Hou MS Yin Li MS |
| author_facet | Chunfeng Yu MS Wei Liu MS Yuejun Mu MS Aihua Hou MS Yin Li MS |
| author_sort | Chunfeng Yu MS |
| collection | DOAJ |
| description | Background: To observe clinical effects of Shen Cao granules on thrombocytopenia in patients with gastrointestinal cancer undergoing chemotherapy. Patients and Methods: Patients under a FOLFIRI chemotherapy regimen (n = 92) were randomly divided into study and control groups (n = 46 for each group) and were given 10 g of Shen Cao granules and a placebo, respectively, once daily on chemotherapy treatment days. Platelet counts were measured every other day and any adverse reaction recorded during the study and at follow-up. Results: The incidence of thrombocytopenia (grades II-IV) in the study group was significantly decreased, and the length of hospitalization significantly reduced compared with the control group (11.21 ± 2.46 vs 15.34 ± 3.68 days, P < .05). The minimum numbers of post-chemotherapy platelets and the values of platelet counts 21 days after chemotherapy were significantly increased ([100.65 ± 63.16] × 10 9 /L vs [60.21 ±37.22] × 10 9 /L, P < .05; [267.81 ± 81.32] × 10 9 /L vs [146.42 ± 70.54] × 10 9 /L, P < .001), and the duration of thrombocytopenia and treatment with recombinant human interleukin-11 was significantly decreased in the Shen Cao treatment compared with the control group. No serious adverse events were observed. Conclusions: Shen Cao granules were effective in decreasing chemotherapy-induced thrombocytopenia, shortened the duration of thrombocytopenia, and reduced the length of hospital stay and costs. |
| first_indexed | 2024-12-12T17:51:29Z |
| format | Article |
| id | doaj.art-a0c1b7d70ca741378346e8f7ad05e449 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-12-12T17:51:29Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-a0c1b7d70ca741378346e8f7ad05e4492022-12-22T00:16:48ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2019-02-011810.1177/1534735419829568Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled TrialChunfeng Yu MS0Wei Liu MS1Yuejun Mu MS2Aihua Hou MS3Yin Li MS4The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaBackground: To observe clinical effects of Shen Cao granules on thrombocytopenia in patients with gastrointestinal cancer undergoing chemotherapy. Patients and Methods: Patients under a FOLFIRI chemotherapy regimen (n = 92) were randomly divided into study and control groups (n = 46 for each group) and were given 10 g of Shen Cao granules and a placebo, respectively, once daily on chemotherapy treatment days. Platelet counts were measured every other day and any adverse reaction recorded during the study and at follow-up. Results: The incidence of thrombocytopenia (grades II-IV) in the study group was significantly decreased, and the length of hospitalization significantly reduced compared with the control group (11.21 ± 2.46 vs 15.34 ± 3.68 days, P < .05). The minimum numbers of post-chemotherapy platelets and the values of platelet counts 21 days after chemotherapy were significantly increased ([100.65 ± 63.16] × 10 9 /L vs [60.21 ±37.22] × 10 9 /L, P < .05; [267.81 ± 81.32] × 10 9 /L vs [146.42 ± 70.54] × 10 9 /L, P < .001), and the duration of thrombocytopenia and treatment with recombinant human interleukin-11 was significantly decreased in the Shen Cao treatment compared with the control group. No serious adverse events were observed. Conclusions: Shen Cao granules were effective in decreasing chemotherapy-induced thrombocytopenia, shortened the duration of thrombocytopenia, and reduced the length of hospital stay and costs.https://doi.org/10.1177/1534735419829568 |
| spellingShingle | Chunfeng Yu MS Wei Liu MS Yuejun Mu MS Aihua Hou MS Yin Li MS Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial Integrative Cancer Therapies |
| title | Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial |
| title_full | Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial |
| title_fullStr | Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial |
| title_full_unstemmed | Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial |
| title_short | Effects of Granules on Chemotherapy-Induced Thrombocytopenia in Gastrointestinal Cancer Patients: A Randomized Controlled Trial |
| title_sort | effects of granules on chemotherapy induced thrombocytopenia in gastrointestinal cancer patients a randomized controlled trial |
| url | https://doi.org/10.1177/1534735419829568 |
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