Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/5/536 |
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| author | Aalaa A. El-Attar Hamdy B. El-Wakil Ahmed H. Hassanin Basant A. Bakr Tahani M. Almutairi Mohamed Hagar Bassma H. Elwakil Zakia A. Olama |
| author_facet | Aalaa A. El-Attar Hamdy B. El-Wakil Ahmed H. Hassanin Basant A. Bakr Tahani M. Almutairi Mohamed Hagar Bassma H. Elwakil Zakia A. Olama |
| author_sort | Aalaa A. El-Attar |
| collection | DOAJ |
| description | Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly biosynthesized silver nanoparticles (Ag-NPs) as a wound healing dressing. Chocolate-band snail (<i>Eobania vermiculata</i>) mucus (which is part of the Mollusca defense system) was used as a novel reducing and stabilizing agent. Data indicated the effectiveness of <i>Eobania vermiculata</i>’s mucus in silver nanoparticle synthesis after a 24 h incubation time. The biosynthesized AgNPs-SM showed a 13.15 nm particle size, −22.5 mV ζ potential, and 0.37 PDI, which proved the stability of the synthesized nanoparticles. <i>Eobania vermiculata</i> mucus and AgNPs-SM showed potent antibacterial activity, especially against <i>Pseudomonas aeruginosa</i>. The electrospinning technique was applied in the fabrication of PVA/AgNPs-SM nanofibers, which were homogenous with a fine diameter of about 100–170 nm and showed a significantly high antimicrobial activity. In vitro and in vivo studies revealed that PVA/AgNPs-SM nanofibers were safe and efficiently enhanced the wound healing process (typical histological picture of the proliferative phase with compact and well aligned collagen fibers in the dermal tissue after 12 days) together with bacterial growth inhibition in the infected skin area. |
| first_indexed | 2024-03-10T03:27:13Z |
| format | Article |
| id | doaj.art-a0c387cab9fe47fea383af2b31628c58 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T03:27:13Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-a0c387cab9fe47fea383af2b31628c582023-11-23T12:06:14ZengMDPI AGMembranes2077-03752022-05-0112553610.3390/membranes12050536Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing ActivitiesAalaa A. El-Attar0Hamdy B. El-Wakil1Ahmed H. Hassanin2Basant A. Bakr3Tahani M. Almutairi4Mohamed Hagar5Bassma H. Elwakil6Zakia A. Olama7Microbiology and Botany Department, Faculty of Science, Alexandria University, Alexandria 21544, EgyptFaculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21500, EgyptCentre of Smart Nanotechnology and Photonics (CSNP), SmartCI Research Centre, Alexandria University, Alexandria 21544, EgyptZoology Department, Faculty of Science, Alexandria University, Alexandria 21544, EgyptDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaChemistry Department, Faculty of Science, Alexandria University, Alexandria 21544, EgyptFaculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21500, EgyptMicrobiology and Botany Department, Faculty of Science, Alexandria University, Alexandria 21544, EgyptHealthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly biosynthesized silver nanoparticles (Ag-NPs) as a wound healing dressing. Chocolate-band snail (<i>Eobania vermiculata</i>) mucus (which is part of the Mollusca defense system) was used as a novel reducing and stabilizing agent. Data indicated the effectiveness of <i>Eobania vermiculata</i>’s mucus in silver nanoparticle synthesis after a 24 h incubation time. The biosynthesized AgNPs-SM showed a 13.15 nm particle size, −22.5 mV ζ potential, and 0.37 PDI, which proved the stability of the synthesized nanoparticles. <i>Eobania vermiculata</i> mucus and AgNPs-SM showed potent antibacterial activity, especially against <i>Pseudomonas aeruginosa</i>. The electrospinning technique was applied in the fabrication of PVA/AgNPs-SM nanofibers, which were homogenous with a fine diameter of about 100–170 nm and showed a significantly high antimicrobial activity. In vitro and in vivo studies revealed that PVA/AgNPs-SM nanofibers were safe and efficiently enhanced the wound healing process (typical histological picture of the proliferative phase with compact and well aligned collagen fibers in the dermal tissue after 12 days) together with bacterial growth inhibition in the infected skin area.https://www.mdpi.com/2077-0375/12/5/536<i>Eobania vermiculata</i>silver nanoparticleselectrospinningPVA nanofibersantibacterial activitywound healing dressing |
| spellingShingle | Aalaa A. El-Attar Hamdy B. El-Wakil Ahmed H. Hassanin Basant A. Bakr Tahani M. Almutairi Mohamed Hagar Bassma H. Elwakil Zakia A. Olama Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities Membranes <i>Eobania vermiculata</i> silver nanoparticles electrospinning PVA nanofibers antibacterial activity wound healing dressing |
| title | Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities |
| title_full | Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities |
| title_fullStr | Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities |
| title_full_unstemmed | Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities |
| title_short | Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities |
| title_sort | silver snail mucous pva nanofibers electrospun synthesis and antibacterial and wound healing activities |
| topic | <i>Eobania vermiculata</i> silver nanoparticles electrospinning PVA nanofibers antibacterial activity wound healing dressing |
| url | https://www.mdpi.com/2077-0375/12/5/536 |
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