Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population.Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were follo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.00024/full |
| _version_ | 1818958721373437952 |
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| author | Qin Lan Qin Lan Hong Wu Xiaohui Zhou Xiaohui Zhou Liang Zheng Liang Zheng Fang Lin Fang Lin Qingshu Meng Qingshu Meng Xiaoling Xi Xiaoling Xi Aixue Yue Aixue Yue Nicholas Buys Jing Sun Zhongmin Liu Zhongmin Liu Jue Li Huimin Fan Huimin Fan |
| author_facet | Qin Lan Qin Lan Hong Wu Xiaohui Zhou Xiaohui Zhou Liang Zheng Liang Zheng Fang Lin Fang Lin Qingshu Meng Qingshu Meng Xiaoling Xi Xiaoling Xi Aixue Yue Aixue Yue Nicholas Buys Jing Sun Zhongmin Liu Zhongmin Liu Jue Li Huimin Fan Huimin Fan |
| author_sort | Qin Lan |
| collection | DOAJ |
| description | Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population.Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease.Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women.Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men. |
| first_indexed | 2024-12-20T11:30:15Z |
| format | Article |
| id | doaj.art-a0c4d091300445828f3f09c657be3463 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T11:30:15Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a0c4d091300445828f3f09c657be34632022-12-21T19:42:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-02-01710.3389/fmed.2020.00024490609Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort StudyQin Lan0Qin Lan1Hong Wu2Xiaohui Zhou3Xiaohui Zhou4Liang Zheng5Liang Zheng6Fang Lin7Fang Lin8Qingshu Meng9Qingshu Meng10Xiaoling Xi11Xiaoling Xi12Aixue Yue13Aixue Yue14Nicholas Buys15Jing Sun16Zhongmin Liu17Zhongmin Liu18Jue Li19Huimin Fan20Huimin Fan21Shanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaGaohang Community Hospital, Pudong New Area, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaSchool of Medicine, Griffith University, Gold Coast, QLD, AustraliaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaShanghai East Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaAim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population.Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease.Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women.Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men.https://www.frontiersin.org/article/10.3389/fmed.2020.00024/fulluric acidcardiometabolic diseasecommunity older populationpredictorcohort study |
| spellingShingle | Qin Lan Qin Lan Hong Wu Xiaohui Zhou Xiaohui Zhou Liang Zheng Liang Zheng Fang Lin Fang Lin Qingshu Meng Qingshu Meng Xiaoling Xi Xiaoling Xi Aixue Yue Aixue Yue Nicholas Buys Jing Sun Zhongmin Liu Zhongmin Liu Jue Li Huimin Fan Huimin Fan Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study Frontiers in Medicine uric acid cardiometabolic disease community older population predictor cohort study |
| title | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
| title_full | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
| title_fullStr | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
| title_full_unstemmed | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
| title_short | Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study |
| title_sort | predictive value of uric acid regarding cardiometabolic disease in a community dwelling older population in shanghai a cohort study |
| topic | uric acid cardiometabolic disease community older population predictor cohort study |
| url | https://www.frontiersin.org/article/10.3389/fmed.2020.00024/full |
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