Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review
Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive mater...
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MDPI AG
2021-01-01
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| author | Nuha Al-Harbi Hiba Mohammed Yas Al-Hadeethi Ahmed Samir Bakry Ahmad Umar Mahmoud Ali Hussein Mona Aly Abbassy Karthik Gurunath Vaidya Ghada Al Berakdar Elmoiz Merghni Mkawi Manasa Nune |
| author_facet | Nuha Al-Harbi Hiba Mohammed Yas Al-Hadeethi Ahmed Samir Bakry Ahmad Umar Mahmoud Ali Hussein Mona Aly Abbassy Karthik Gurunath Vaidya Ghada Al Berakdar Elmoiz Merghni Mkawi Manasa Nune |
| author_sort | Nuha Al-Harbi |
| collection | DOAJ |
| description | Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide and is mainly referred to by its commercial name Bioglass. BG is mainly used for bone tissue regeneration due to its osteoconductivity and osteostimulation properties. The bioactivity of BG, however, is highly dependent on the compositional ratio of certain glass-forming system content. The manipulation of content ratio and the element compositional flexibility of BG-forming network developed other types of bioactive glasses with controllable chemical durability and chemical affinity with bone and bioactivity. This review article mainly discusses the basic information about silica-based bioactive glasses, including their composition, processing, and properties, as well as their medical applications such as in bone regeneration, as bone grafts, and as dental implant coatings. |
| first_indexed | 2024-03-09T04:15:16Z |
| format | Article |
| id | doaj.art-a0c5bafb8eaa41f28b883468c5e94adf |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T04:15:16Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a0c5bafb8eaa41f28b883468c5e94adf2023-12-03T13:55:25ZengMDPI AGPharmaceuticals1424-82472021-01-011427510.3390/ph14020075Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A ReviewNuha Al-Harbi0Hiba Mohammed1Yas Al-Hadeethi2Ahmed Samir Bakry3Ahmad Umar4Mahmoud Ali Hussein5Mona Aly Abbassy6Karthik Gurunath Vaidya7Ghada Al Berakdar8Elmoiz Merghni Mkawi9Manasa Nune10Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaFondazione Novara Sviluppo, 28100 Novara, ItalyDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaOperative Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Chemistry, Faculty of Science and Arts, Najran University, P.O. Box 1988, Najran 11001, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi ArabiaManipal Institute of Regenerative Medicine (MIRM), Manipal Academy of Higher Education (MAHE), Allalasandra GKVK Post, Yelahanka, Bengaluru 560065, IndiaDepartment of Dentistry, University Medical Services Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaManipal Institute of Regenerative Medicine (MIRM), Manipal Academy of Higher Education (MAHE), Allalasandra GKVK Post, Yelahanka, Bengaluru 560065, IndiaRegenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide and is mainly referred to by its commercial name Bioglass. BG is mainly used for bone tissue regeneration due to its osteoconductivity and osteostimulation properties. The bioactivity of BG, however, is highly dependent on the compositional ratio of certain glass-forming system content. The manipulation of content ratio and the element compositional flexibility of BG-forming network developed other types of bioactive glasses with controllable chemical durability and chemical affinity with bone and bioactivity. This review article mainly discusses the basic information about silica-based bioactive glasses, including their composition, processing, and properties, as well as their medical applications such as in bone regeneration, as bone grafts, and as dental implant coatings.https://www.mdpi.com/1424-8247/14/2/75regenerative medicinehard tissue regenerationbioactive glassesosteoconductivityosteostimulationmedical applications |
| spellingShingle | Nuha Al-Harbi Hiba Mohammed Yas Al-Hadeethi Ahmed Samir Bakry Ahmad Umar Mahmoud Ali Hussein Mona Aly Abbassy Karthik Gurunath Vaidya Ghada Al Berakdar Elmoiz Merghni Mkawi Manasa Nune Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review Pharmaceuticals regenerative medicine hard tissue regeneration bioactive glasses osteoconductivity osteostimulation medical applications |
| title | Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review |
| title_full | Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review |
| title_fullStr | Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review |
| title_full_unstemmed | Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review |
| title_short | Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review |
| title_sort | silica based bioactive glasses and their applications in hard tissue regeneration a review |
| topic | regenerative medicine hard tissue regeneration bioactive glasses osteoconductivity osteostimulation medical applications |
| url | https://www.mdpi.com/1424-8247/14/2/75 |
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