Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study
Xiting Wang, Hao Wang, Qin Zheng, Hui Geng, Jing Zhang, Yan Fan, Xueru Feng, Xiahuan Chen, Meilin Liu Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Meilin Liu, Department of Geriatrics, Peking University First Hospital, Beijing, People...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-09-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/outcomes-associated-with-50-mgd-and-100-mgd-aspirin-for-the-prevention-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1811276898425110528 |
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| author | Wang X Wang H Zheng Q Geng H Zhang J Fan Y Feng X Chen X Liu M |
| author_facet | Wang X Wang H Zheng Q Geng H Zhang J Fan Y Feng X Chen X Liu M |
| author_sort | Wang X |
| collection | DOAJ |
| description | Xiting Wang, Hao Wang, Qin Zheng, Hui Geng, Jing Zhang, Yan Fan, Xueru Feng, Xiahuan Chen, Meilin Liu Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Meilin Liu, Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of China, Email liumeilin@hotmail.comPurpose: Although aspirin can effectively reduce the occurrence of atherothrombosis, it is significantly associated with increased bleeding, with elderly individuals being at increased risk of cardiovascular diseases (CVD) and hemorrhage. This study aims to evaluate the efficacy and safety of aspirin 50 mg/d and 100 mg/d for the prevention and management of CVD in Chinese elderly.Patients and Methods: The Low-dose Aspirin for Primary and Secondary Prevention of Cardiovascular Disease in the Elderly Study (LAPIS) is a multicenter, prospective, observational cohort study, this study was a single-center interim analysis of LAPIS. Patients aged ≥ 60 and required long-term aspirin for primary and secondary prevention of CVD were eligible. From Apr 1, 2019 to Feb 28, 2022, 165 patients who received 50 mg/d aspirin and 261 patients who received 100 mg/d aspirin were included in the study. The incidence of major cardiovascular events (MACEs), bleeding events, and gastrointestinal adverse events were compared between two groups.Results: After adjusting for patient characteristics using propensity score matching, aspirin 100 mg/d was associated with increased incidence rates of total bleeding events (28.34 vs.17.25 events/100 patient-years, HR 1.671, 95% CI 1.024– 2.712, P = 0.040) and minor bleeding events (27.63 vs.15.92 events/100 patient-years, HR 1.738, 95% CI 1.056– 2.861, P = 0.031), whereas the incidence of MACE (6.35 vs 6.65 events/100 patient-years, HR 0.921, 95% CI 0.399– 2.127, P = 0.848) and gastrointestinal adverse events (12.73 vs.10.42 events/100 patient-years, HR 1.206, 95% CI 0.623– 2.337, P = 0.578) were similar between the two groups. Multivariate Cox analysis identified that aspirin dose (100 mg/d vs. 50 mg/d, HR 1.918, 95% CI 1.137– 3.235, P = 0.015), concomitant use of other antiplatelets (HR 1.748, 95% CI 1.009– 3.028, P = 0.046) and anticoagulants (HR 2.501, 95% CI 1.287– 4.862, P = 0.007) were independently associated with bleeding events.Conclusion: 50 mg/d aspirin may be preferred to balance the safety and effectiveness in Chinese individuals over 60 years of age who need long-term aspirin for the prevention and management of CVD.Trial Registration: ChiCTR1900021980 (chictr.org.cn). Registered on 19 March 2019.Keywords: low-dose aspirin, effectiveness outcome, safety outcome, Chinese elderly |
| first_indexed | 2024-04-13T00:07:06Z |
| format | Article |
| id | doaj.art-a0c75041468c45848c28386c284ee2a6 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T00:07:06Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
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| series | International Journal of General Medicine |
| spelling | doaj.art-a0c75041468c45848c28386c284ee2a62022-12-22T03:11:13ZengDove Medical PressInternational Journal of General Medicine1178-70742022-09-01Volume 157089710077996Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational StudyWang XWang HZheng QGeng HZhang JFan YFeng XChen XLiu MXiting Wang, Hao Wang, Qin Zheng, Hui Geng, Jing Zhang, Yan Fan, Xueru Feng, Xiahuan Chen, Meilin Liu Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Meilin Liu, Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of China, Email liumeilin@hotmail.comPurpose: Although aspirin can effectively reduce the occurrence of atherothrombosis, it is significantly associated with increased bleeding, with elderly individuals being at increased risk of cardiovascular diseases (CVD) and hemorrhage. This study aims to evaluate the efficacy and safety of aspirin 50 mg/d and 100 mg/d for the prevention and management of CVD in Chinese elderly.Patients and Methods: The Low-dose Aspirin for Primary and Secondary Prevention of Cardiovascular Disease in the Elderly Study (LAPIS) is a multicenter, prospective, observational cohort study, this study was a single-center interim analysis of LAPIS. Patients aged ≥ 60 and required long-term aspirin for primary and secondary prevention of CVD were eligible. From Apr 1, 2019 to Feb 28, 2022, 165 patients who received 50 mg/d aspirin and 261 patients who received 100 mg/d aspirin were included in the study. The incidence of major cardiovascular events (MACEs), bleeding events, and gastrointestinal adverse events were compared between two groups.Results: After adjusting for patient characteristics using propensity score matching, aspirin 100 mg/d was associated with increased incidence rates of total bleeding events (28.34 vs.17.25 events/100 patient-years, HR 1.671, 95% CI 1.024– 2.712, P = 0.040) and minor bleeding events (27.63 vs.15.92 events/100 patient-years, HR 1.738, 95% CI 1.056– 2.861, P = 0.031), whereas the incidence of MACE (6.35 vs 6.65 events/100 patient-years, HR 0.921, 95% CI 0.399– 2.127, P = 0.848) and gastrointestinal adverse events (12.73 vs.10.42 events/100 patient-years, HR 1.206, 95% CI 0.623– 2.337, P = 0.578) were similar between the two groups. Multivariate Cox analysis identified that aspirin dose (100 mg/d vs. 50 mg/d, HR 1.918, 95% CI 1.137– 3.235, P = 0.015), concomitant use of other antiplatelets (HR 1.748, 95% CI 1.009– 3.028, P = 0.046) and anticoagulants (HR 2.501, 95% CI 1.287– 4.862, P = 0.007) were independently associated with bleeding events.Conclusion: 50 mg/d aspirin may be preferred to balance the safety and effectiveness in Chinese individuals over 60 years of age who need long-term aspirin for the prevention and management of CVD.Trial Registration: ChiCTR1900021980 (chictr.org.cn). Registered on 19 March 2019.Keywords: low-dose aspirin, effectiveness outcome, safety outcome, Chinese elderlyhttps://www.dovepress.com/outcomes-associated-with-50-mgd-and-100-mgd-aspirin-for-the-prevention-peer-reviewed-fulltext-article-IJGMlow-dose aspirineffectiveness outcomesafety outcomechinese elderly |
| spellingShingle | Wang X Wang H Zheng Q Geng H Zhang J Fan Y Feng X Chen X Liu M Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study International Journal of General Medicine low-dose aspirin effectiveness outcome safety outcome chinese elderly |
| title | Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study |
| title_full | Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study |
| title_fullStr | Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study |
| title_full_unstemmed | Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study |
| title_short | Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study |
| title_sort | outcomes associated with 50 mg d and 100 mg d aspirin for the prevention and management of cardiovascular disease in chinese elderly single center interim analysis of a multicenter prospective observational study |
| topic | low-dose aspirin effectiveness outcome safety outcome chinese elderly |
| url | https://www.dovepress.com/outcomes-associated-with-50-mgd-and-100-mgd-aspirin-for-the-prevention-peer-reviewed-fulltext-article-IJGM |
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