COUP-TFII in Kidneys, from Embryos to Sick Adults
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan nuclear hormone receptor of unknown ligands. This molecule has two interesting features: (1) it is a developmental gene, and (2) it is a potential hormone receptor. Here, we describe the possible roles of COUP-TFII...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1181 |
| _version_ | 1797500451149578240 |
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| author | Sumiyasu Ishii Noriyuki Koibuchi |
| author_facet | Sumiyasu Ishii Noriyuki Koibuchi |
| author_sort | Sumiyasu Ishii |
| collection | DOAJ |
| description | Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan nuclear hormone receptor of unknown ligands. This molecule has two interesting features: (1) it is a developmental gene, and (2) it is a potential hormone receptor. Here, we describe the possible roles of COUP-TFII in the organogenesis of the kidneys and protection from adult renal diseases, primarily in mouse models. COUP-TFII is highly expressed in embryos, including primordial kidneys, and is essential for the formation of metanephric mesenchyme and the survival of renal precursor cells. Although the expression levels of COUP-TFII are low and its functions are unknown in healthy adults, it serves as a reno-protectant molecule against acute kidney injury. These are good examples of how developmental genes exhibit novel functions in the etiology of adult diseases. We also discuss the ongoing research on the roles of COUP-TFII in podocyte development and diabetic kidney disease. In addition, the identification of potential ligands suggests that COUP-TFII might be a novel therapeutic target for renal diseases in the future. |
| first_indexed | 2024-03-10T03:03:05Z |
| format | Article |
| id | doaj.art-a0c7f6f43a9f41e486887816da82f7e9 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:03:05Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a0c7f6f43a9f41e486887816da82f7e92023-11-23T10:40:31ZengMDPI AGDiagnostics2075-44182022-05-01125118110.3390/diagnostics12051181COUP-TFII in Kidneys, from Embryos to Sick AdultsSumiyasu Ishii0Noriyuki Koibuchi1Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8501, JapanDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8501, JapanChicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan nuclear hormone receptor of unknown ligands. This molecule has two interesting features: (1) it is a developmental gene, and (2) it is a potential hormone receptor. Here, we describe the possible roles of COUP-TFII in the organogenesis of the kidneys and protection from adult renal diseases, primarily in mouse models. COUP-TFII is highly expressed in embryos, including primordial kidneys, and is essential for the formation of metanephric mesenchyme and the survival of renal precursor cells. Although the expression levels of COUP-TFII are low and its functions are unknown in healthy adults, it serves as a reno-protectant molecule against acute kidney injury. These are good examples of how developmental genes exhibit novel functions in the etiology of adult diseases. We also discuss the ongoing research on the roles of COUP-TFII in podocyte development and diabetic kidney disease. In addition, the identification of potential ligands suggests that COUP-TFII might be a novel therapeutic target for renal diseases in the future.https://www.mdpi.com/2075-4418/12/5/1181chicken ovalbumin upstream promoter–transcription factor (COUP-TF)orphan nuclear hormone receptorkidneyorganogenesisacute kidney injurypodocyte |
| spellingShingle | Sumiyasu Ishii Noriyuki Koibuchi COUP-TFII in Kidneys, from Embryos to Sick Adults Diagnostics chicken ovalbumin upstream promoter–transcription factor (COUP-TF) orphan nuclear hormone receptor kidney organogenesis acute kidney injury podocyte |
| title | COUP-TFII in Kidneys, from Embryos to Sick Adults |
| title_full | COUP-TFII in Kidneys, from Embryos to Sick Adults |
| title_fullStr | COUP-TFII in Kidneys, from Embryos to Sick Adults |
| title_full_unstemmed | COUP-TFII in Kidneys, from Embryos to Sick Adults |
| title_short | COUP-TFII in Kidneys, from Embryos to Sick Adults |
| title_sort | coup tfii in kidneys from embryos to sick adults |
| topic | chicken ovalbumin upstream promoter–transcription factor (COUP-TF) orphan nuclear hormone receptor kidney organogenesis acute kidney injury podocyte |
| url | https://www.mdpi.com/2075-4418/12/5/1181 |
| work_keys_str_mv | AT sumiyasuishii couptfiiinkidneysfromembryostosickadults AT noriyukikoibuchi couptfiiinkidneysfromembryostosickadults |