Sphingosine-1-Phosphate Receptor Type 4 (S1P<sub>4</sub>) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions

Sphingosine-1-Phosphate Receptor Type 4 (S1P<sub>4</sub>) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions

Background: Gram-negative infections of the peritoneal cavity result in profound modifications of peritoneal B cell populations and induce the migration of peritoneal B cells to distant secondary lymphoid organs. However, mechanisms controlling the egress of peritoneal B cells from the peritoneal ca...

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Bibliographic Details
Main Authors: Janik Riese, Alina Gromann, Felix Lührs, Annabel Kleinwort, Tobias Schulze
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine-1-phosphate
peritoneal B cells
abdominal sepsis
lymphocyte trafficking
innate response activator B cells (IRA B cells)
Online Access:https://www.mdpi.com/1422-0067/22/7/3465

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