Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?
ABSTRACT Objective To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200145&lng=en&tlng=en |
| _version_ | 1818414229077622784 |
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| author | Murat Sahin Didem Demircioglu Ayten Oguz Dilek Tuzun Mehmet Akif Sarica Elif Inanc Kamile Gul |
| author_facet | Murat Sahin Didem Demircioglu Ayten Oguz Dilek Tuzun Mehmet Akif Sarica Elif Inanc Kamile Gul |
| author_sort | Murat Sahin |
| collection | DOAJ |
| description | ABSTRACT Objective To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants. Results Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05). Conclusion This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well. |
| first_indexed | 2024-12-14T11:15:46Z |
| format | Article |
| id | doaj.art-a0c92e01f1d64ed3abe2585d40fa8c9b |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-14T11:15:46Z |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-a0c92e01f1d64ed3abe2585d40fa8c9b2022-12-21T23:04:03ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-429261214515110.1590/2359-3997000000225S2359-39972017000200145Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?Murat SahinDidem DemirciogluAyten OguzDilek TuzunMehmet Akif SaricaElif InancKamile GulABSTRACT Objective To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants. Results Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05). Conclusion This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200145&lng=en&tlng=enPolycystic ovarian syndromethyroid volumeinsulin resistanceluteinizing hormone |
| spellingShingle | Murat Sahin Didem Demircioglu Ayten Oguz Dilek Tuzun Mehmet Akif Sarica Elif Inanc Kamile Gul Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? Archives of Endocrinology and Metabolism Polycystic ovarian syndrome thyroid volume insulin resistance luteinizing hormone |
| title | Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? |
| title_full | Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? |
| title_fullStr | Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? |
| title_full_unstemmed | Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? |
| title_short | Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome? |
| title_sort | does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome |
| topic | Polycystic ovarian syndrome thyroid volume insulin resistance luteinizing hormone |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000200145&lng=en&tlng=en |
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