Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study
OBJECTIVE: The objective of the study is to test the efficacy of high-dose methylprednisolone in the prevention of esophageal stricture after corrosive ingestion. METHODS: This study was a single-center, randomized controlled single-blinded study. Simple randomization was done with 15 adult patients...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Turkish Journal of Emergency Medicine |
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| Online Access: | http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2024;volume=24;issue=1;spage=20;epage=26;aulast=Sheikh |
| _version_ | 1797221299325501440 |
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| author | Irtiqa Sheikh Nayer Jamshed Akhil Neseem Praveen Aggarwal Saurabh Kedia Maroof Ahmad Khan Chandan J Das Ankit Kumar Sahu |
| author_facet | Irtiqa Sheikh Nayer Jamshed Akhil Neseem Praveen Aggarwal Saurabh Kedia Maroof Ahmad Khan Chandan J Das Ankit Kumar Sahu |
| author_sort | Irtiqa Sheikh |
| collection | DOAJ |
| description | OBJECTIVE: The objective of the study is to test the efficacy of high-dose methylprednisolone in the prevention of esophageal stricture after corrosive ingestion.
METHODS: This study was a single-center, randomized controlled single-blinded study. Simple randomization was done with 15 adult patients (>18 years) in each arm, who presented with a history of corrosive ingestion within the past 24 h and had esophageal injury of Zargar Grade IIB on endoscopy. Intravenous methylprednisolone 1 g/day for 3 days was given to the intervention arm while 100 mL of normal saline was given as placebo in control arm. Follow-up to diagnose esophageal stricture was done at 8 weeks.
RESULTS: Thirty patients (15 in each arm) were recruited for the study. As per the intention to treat analysis, 33% and 46.6% developed stricture in the intervention and control arm, respectively (relative risk [RR] = 0.714; 95% confidence interval 0.29–1.75; P = 0.462). 40% patients in control group and 7.7% in intervention group had undergone feeding jejunostomy, which was statistically significant with a p-value of 0.048. Airway injury showed significant clinical improvement in the intervention arm but the difference was nonsignificant statistically (P = 0.674). There was no increased incidence of hypertension, hyperglycemia, hyponatremia, hyperkalemia, or infections in intervention arm.
CONCLUSION: Methylprednisolone does not help in the prevention of stricture formation in corrosive esophageal injury, but it significantly reduces the requirement of feeding jejunostomy and has a beneficial role in treating airway injury. |
| first_indexed | 2024-04-24T13:03:14Z |
| format | Article |
| id | doaj.art-a0c956533385417190a0e31aa7fe66bc |
| institution | Directory Open Access Journal |
| issn | 2452-2473 |
| language | English |
| last_indexed | 2024-04-24T13:03:14Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Turkish Journal of Emergency Medicine |
| spelling | doaj.art-a0c956533385417190a0e31aa7fe66bc2024-04-05T09:59:34ZengWolters Kluwer Medknow PublicationsTurkish Journal of Emergency Medicine2452-24732024-01-01241202610.4103/tjem.tjem_134_23Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control studyIrtiqa SheikhNayer JamshedAkhil NeseemPraveen AggarwalSaurabh KediaMaroof Ahmad KhanChandan J DasAnkit Kumar SahuOBJECTIVE: The objective of the study is to test the efficacy of high-dose methylprednisolone in the prevention of esophageal stricture after corrosive ingestion. METHODS: This study was a single-center, randomized controlled single-blinded study. Simple randomization was done with 15 adult patients (>18 years) in each arm, who presented with a history of corrosive ingestion within the past 24 h and had esophageal injury of Zargar Grade IIB on endoscopy. Intravenous methylprednisolone 1 g/day for 3 days was given to the intervention arm while 100 mL of normal saline was given as placebo in control arm. Follow-up to diagnose esophageal stricture was done at 8 weeks. RESULTS: Thirty patients (15 in each arm) were recruited for the study. As per the intention to treat analysis, 33% and 46.6% developed stricture in the intervention and control arm, respectively (relative risk [RR] = 0.714; 95% confidence interval 0.29–1.75; P = 0.462). 40% patients in control group and 7.7% in intervention group had undergone feeding jejunostomy, which was statistically significant with a p-value of 0.048. Airway injury showed significant clinical improvement in the intervention arm but the difference was nonsignificant statistically (P = 0.674). There was no increased incidence of hypertension, hyperglycemia, hyponatremia, hyperkalemia, or infections in intervention arm. CONCLUSION: Methylprednisolone does not help in the prevention of stricture formation in corrosive esophageal injury, but it significantly reduces the requirement of feeding jejunostomy and has a beneficial role in treating airway injury.http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2024;volume=24;issue=1;spage=20;epage=26;aulast=Sheikhairway injurycorrosive ingestionesophageal burnssteroidsstricturezargar classification |
| spellingShingle | Irtiqa Sheikh Nayer Jamshed Akhil Neseem Praveen Aggarwal Saurabh Kedia Maroof Ahmad Khan Chandan J Das Ankit Kumar Sahu Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study Turkish Journal of Emergency Medicine airway injury corrosive ingestion esophageal burns steroids stricture zargar classification |
| title | Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study |
| title_full | Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study |
| title_fullStr | Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study |
| title_full_unstemmed | Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study |
| title_short | Role of high-dose methylprednisolone in Zargar Grade IIB corrosive esophageal burns: A randomized control study |
| title_sort | role of high dose methylprednisolone in zargar grade iib corrosive esophageal burns a randomized control study |
| topic | airway injury corrosive ingestion esophageal burns steroids stricture zargar classification |
| url | http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2024;volume=24;issue=1;spage=20;epage=26;aulast=Sheikh |
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