Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

<p><b>Abstract</b></p> <p><b>Background</b></p> <p>Adeno-associated vectors (rAAV) have been used to attain long-term liver gene expression. In humans, the cellular immune response poses a serious obstacle for transgene persistence while neutrali...

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Bibliographic Details
Main Authors: Unzu Carmen, Hervás-Stubbs Sandra, Sampedro Ana, Mauleón Itsaso, Mancheño Uxua, Alfaro Carlos, de Salamanca Rafael, Benito Alberto, Beattie Stuart G, Petry Harald, Prieto Jesús, Melero Ignacio, Fontanellas Antonio
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Translational Medicine
Subjects:
Adeno-associated virus serotype 5
Neutralizing antibodies
Re-administration
Vector Immunology/Host Responses
Immunomodulation
Online Access:http://www.translational-medicine.com/content/10/1/122

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