Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes
A series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NMR and UV-Visible spectroscopy, Thermogravimetric analysis, Magn...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2015-06-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
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| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/17878 |
| _version_ | 1797946793529442304 |
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| author | Minaxi S. Maru Manish K. Shah |
| author_facet | Minaxi S. Maru Manish K. Shah |
| author_sort | Minaxi S. Maru |
| collection | DOAJ |
| description | A series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NMR and UV-Visible spectroscopy, Thermogravimetric analysis, Magnetic susceptibility, Molar conductance and Elemental analysis. The 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g have been synthesized by cyclocondensation of benzene-1,2-diamine with 2-chloroquinoline-3-carbaldehydes by using ceric ammonium nitrate as a catalyst in presence of hydrogen peroxide as an oxidant. The structures of all ligands were confirmed by IR, Mass, UV-Visible, 1H NMR and 13C NMR spectroscopy. All ligands 3a-g and their Co(II) complexes 3¢a-g were screened for their in vitro antimicrobial activity using twofold serial dilution technique against standard MTCC strains of two Gram-positive Staphylococcus aureus and Streptococcus pyogenes, two Gram-negative Escherichia coli and Pseudomonas aeruginosa bacteria and three Candida albicans, Aspergillus niger and Aspergillus clavatus fungus in comparison with standard drugs. All ligands 3a-g and complexes 3¢a-g also evaluated for antimycobacterial activity against standard Mycobacterium tuberculosis H37Rv strain.
DOI: http://dx.doi.org/10.17807/orbital.v7i2.530
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| first_indexed | 2024-04-10T21:16:34Z |
| format | Article |
| id | doaj.art-a0caabbb97ba4f9e93ba331949021761 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:16:34Z |
| publishDate | 2015-06-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-a0caabbb97ba4f9e93ba3319490217612023-01-20T11:04:58ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282015-06-0172Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) ComplexesMinaxi S. Maru0Manish K. Shah1Lab. No. 302, Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, G. B. Marg, Waghawadi Road, Bhavnagar-364002, Gujarat, INDIADepartment of Chemistry, Saurashtra UniversityA series of Co(II) complexes 3¢a-g of 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g were prepared and characterized by various spectroscopic and physico-chemical methods viz. FT-IR, ESI mass, 1H NMR, 13C NMR and UV-Visible spectroscopy, Thermogravimetric analysis, Magnetic susceptibility, Molar conductance and Elemental analysis. The 2-(2-chloro-6,7-substituted quinolin-3-yl)-1H-benzo[d]imidazole ligands 3a-g have been synthesized by cyclocondensation of benzene-1,2-diamine with 2-chloroquinoline-3-carbaldehydes by using ceric ammonium nitrate as a catalyst in presence of hydrogen peroxide as an oxidant. The structures of all ligands were confirmed by IR, Mass, UV-Visible, 1H NMR and 13C NMR spectroscopy. All ligands 3a-g and their Co(II) complexes 3¢a-g were screened for their in vitro antimicrobial activity using twofold serial dilution technique against standard MTCC strains of two Gram-positive Staphylococcus aureus and Streptococcus pyogenes, two Gram-negative Escherichia coli and Pseudomonas aeruginosa bacteria and three Candida albicans, Aspergillus niger and Aspergillus clavatus fungus in comparison with standard drugs. All ligands 3a-g and complexes 3¢a-g also evaluated for antimycobacterial activity against standard Mycobacterium tuberculosis H37Rv strain. DOI: http://dx.doi.org/10.17807/orbital.v7i2.530 https://periodicos.ufms.br/index.php/orbital/article/view/17878Co(II) complexes1H-benzo[d]imidazolesantimicrobial activityantimycobacterial activity |
| spellingShingle | Minaxi S. Maru Manish K. Shah Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes Orbital: The Electronic Journal of Chemistry Co(II) complexes 1H-benzo[d]imidazoles antimicrobial activity antimycobacterial activity |
| title | Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes |
| title_full | Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes |
| title_fullStr | Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes |
| title_full_unstemmed | Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes |
| title_short | Synthesis, Characterization and Biological Evaluation of Mononuclear Dichloro-bis[2-(2-chloro-6,7-substituted Quinolin-3-yl)-1H-benzo[d]imidazole]Co(II) Complexes |
| title_sort | synthesis characterization and biological evaluation of mononuclear dichloro bis 2 2 chloro 6 7 substituted quinolin 3 yl 1h benzo d imidazole co ii complexes |
| topic | Co(II) complexes 1H-benzo[d]imidazoles antimicrobial activity antimycobacterial activity |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/17878 |
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