The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging

The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging

Skeletal muscle dysfunction, articular cartilage degeneration, and bone loss occur essentially in parallel during aging. Mechanisms contributing to this systemic musculoskeletal decline remain incompletely understood, limiting progress toward developing effective therapeutics. Because the progressio...

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Bibliographic Details
Main Authors: Robert V. Musci, Maureen A. Walsh, Adam R. Konopka, Christopher A. Wolff, Frederick F. Peelor, Raoul F. Reiser, Kelly S. Santangelo, Karyn L. Hamilton
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
aging
skeletal muscle
protein synthesis
musculoskeletal
osteoarthritis
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.571372/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.571372/full

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