The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer
Purpose/aim: To examine with immunohistochemical assay MTA1 protein expression levels in pancreatic cancer tissues defining its prognostic value. Material and Methods: The specimens derived from 51 patients who underwent surgery. The levels of MTA1 protein were compared with the age of the patients,...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2018-03-01
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Series: | Journal of Investigative Surgery |
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Online Access: | http://dx.doi.org/10.1080/08941939.2017.1280565 |
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author | Efstathios T. Pavlidis Maria Lambropoulou Nikolaos G. Symeonidis Constantinos Anagnostopoulos Alexandra Tsaroucha Athanasia Kotini Christina Nikolaidou Anastasia Kiziridou Constantinos Simopoulos |
author_facet | Efstathios T. Pavlidis Maria Lambropoulou Nikolaos G. Symeonidis Constantinos Anagnostopoulos Alexandra Tsaroucha Athanasia Kotini Christina Nikolaidou Anastasia Kiziridou Constantinos Simopoulos |
author_sort | Efstathios T. Pavlidis |
collection | DOAJ |
description | Purpose/aim: To examine with immunohistochemical assay MTA1 protein expression levels in pancreatic cancer tissues defining its prognostic value. Material and Methods: The specimens derived from 51 patients who underwent surgery. The levels of MTA1 protein were compared with the age of the patients, their survival, and prognosis. Also, we studied clinical and histopathological factors such as the degree of tumor differentiation and its stage in correlation with MTA1 protein levels. In parallel, there was correlation between the expression of the ΜΤΑ1 protein and the aforementioned factors regarding survival rate. Furthermore, we independently correlated the patient's survival in relation to whether they had undergone adjuvant chemotherapy or not. Results: It has been found to be low, moderate, or high expression of MTA1 levels in 48 out of 51 cancer tissues. Specifically, 49.0% of patients had low expression, 33.3% moderate, and 11.8% high expression of MTA1. Regarding the expression of MTA1 protein in correlation with various clinical and histopathological factors, a statistically significant correlation was observed with the degree of differentiation (p = 0.0068) and with the stage of the disease (p = 0.0173), but not with survival (p = 0.0740) or the age of them (p = 0.1547). Finally, it was found that overexpression of the MTA1protein is a prognostic factor for shorter survival in patients with pancreatic cancer (average 4.67 ± 0.95 months). Conclusions: MTA 1 protein may constitute an important prognostic marker in pancreatic cancer and could improve prognosis and treatment. |
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issn | 0894-1939 1521-0553 |
language | English |
last_indexed | 2024-03-12T00:32:22Z |
publishDate | 2018-03-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Journal of Investigative Surgery |
spelling | doaj.art-a0cca21828f7477d93a06f95792227d62023-09-15T10:12:27ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532018-03-0131214215010.1080/08941939.2017.12805651280565The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic CancerEfstathios T. Pavlidis0Maria Lambropoulou1Nikolaos G. Symeonidis2Constantinos Anagnostopoulos3Alexandra Tsaroucha4Athanasia Kotini5Christina Nikolaidou6Anastasia Kiziridou7Constantinos Simopoulos8Democritus University of ThraceLaboratories of Histology-EmbryologyDemocritus University of ThraceLaboratories of BiochemistryTheagenio Anticancer HospitalTheagenio Anticancer HospitalLaboratories of Histology-EmbryologyTheagenio Anticancer HospitalDemocritus University of ThracePurpose/aim: To examine with immunohistochemical assay MTA1 protein expression levels in pancreatic cancer tissues defining its prognostic value. Material and Methods: The specimens derived from 51 patients who underwent surgery. The levels of MTA1 protein were compared with the age of the patients, their survival, and prognosis. Also, we studied clinical and histopathological factors such as the degree of tumor differentiation and its stage in correlation with MTA1 protein levels. In parallel, there was correlation between the expression of the ΜΤΑ1 protein and the aforementioned factors regarding survival rate. Furthermore, we independently correlated the patient's survival in relation to whether they had undergone adjuvant chemotherapy or not. Results: It has been found to be low, moderate, or high expression of MTA1 levels in 48 out of 51 cancer tissues. Specifically, 49.0% of patients had low expression, 33.3% moderate, and 11.8% high expression of MTA1. Regarding the expression of MTA1 protein in correlation with various clinical and histopathological factors, a statistically significant correlation was observed with the degree of differentiation (p = 0.0068) and with the stage of the disease (p = 0.0173), but not with survival (p = 0.0740) or the age of them (p = 0.1547). Finally, it was found that overexpression of the MTA1protein is a prognostic factor for shorter survival in patients with pancreatic cancer (average 4.67 ± 0.95 months). Conclusions: MTA 1 protein may constitute an important prognostic marker in pancreatic cancer and could improve prognosis and treatment.http://dx.doi.org/10.1080/08941939.2017.1280565pancreatic cancermta 1 proteinmolecular prognostic markersmta protein familygene expressionmetastatic capacity |
spellingShingle | Efstathios T. Pavlidis Maria Lambropoulou Nikolaos G. Symeonidis Constantinos Anagnostopoulos Alexandra Tsaroucha Athanasia Kotini Christina Nikolaidou Anastasia Kiziridou Constantinos Simopoulos The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer Journal of Investigative Surgery pancreatic cancer mta 1 protein molecular prognostic markers mta protein family gene expression metastatic capacity |
title | The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer |
title_full | The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer |
title_fullStr | The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer |
title_full_unstemmed | The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer |
title_short | The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer |
title_sort | immunohistochemical expression mta 1 protein and its prognostic value in pancreatic cancer |
topic | pancreatic cancer mta 1 protein molecular prognostic markers mta protein family gene expression metastatic capacity |
url | http://dx.doi.org/10.1080/08941939.2017.1280565 |
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