MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation
Diagnosis and treatment of prostate cancer (PCа) are associated with the serum level of prostate specific antigen (PSA). However, certain prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis can also affect PSA levels. The low specificity and sensitivity of PSA leads to a &qu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2023-10-01
|
| Series: | Vestnik Urologii |
| Subjects: | |
| Online Access: | https://www.urovest.ru/jour/article/view/760 |
| _version_ | 1797272092267249664 |
|---|---|
| author | Z. M. Akhokhov R. S. Ismailov M. I. Kogan |
| author_facet | Z. M. Akhokhov R. S. Ismailov M. I. Kogan |
| author_sort | Z. M. Akhokhov |
| collection | DOAJ |
| description | Diagnosis and treatment of prostate cancer (PCа) are associated with the serum level of prostate specific antigen (PSA). However, certain prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis can also affect PSA levels. The low specificity and sensitivity of PSA leads to a "unnecessary" prostate biopsy, which certainly makes this diagnostic method a controversial screening test. As a result, the discovery of new non-invasive molecular biological markers are necessary for the diagnosis, treatment, surveillance and prognosis of patients with diseases of prostate. This review aims to evaluate the "benefit" of miRNAs as molecular biological markers of BPH and PCa differentiation. |
| first_indexed | 2024-03-07T14:23:28Z |
| format | Article |
| id | doaj.art-a0ce2708c5af4b9e96d3fc9047dd162a |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2024-03-07T14:23:28Z |
| publishDate | 2023-10-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Vestnik Urologii |
| spelling | doaj.art-a0ce2708c5af4b9e96d3fc9047dd162a2024-03-06T08:56:06ZrusState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationVestnik Urologii2308-64242023-10-011139810710.21886/2308-6424-2023-11-3-98-107470MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiationZ. M. Akhokhov0R. S. Ismailov1M. I. Kogan2Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityDiagnosis and treatment of prostate cancer (PCа) are associated with the serum level of prostate specific antigen (PSA). However, certain prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis can also affect PSA levels. The low specificity and sensitivity of PSA leads to a "unnecessary" prostate biopsy, which certainly makes this diagnostic method a controversial screening test. As a result, the discovery of new non-invasive molecular biological markers are necessary for the diagnosis, treatment, surveillance and prognosis of patients with diseases of prostate. This review aims to evaluate the "benefit" of miRNAs as molecular biological markers of BPH and PCa differentiation.https://www.urovest.ru/jour/article/view/760mirnabenign prostatic hyperplasiaprostate cancerlower urinary tract symptomsprostate specific antigenmolecular biological markersribonucleic acidreview |
| spellingShingle | Z. M. Akhokhov R. S. Ismailov M. I. Kogan MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation Vestnik Urologii mirna benign prostatic hyperplasia prostate cancer lower urinary tract symptoms prostate specific antigen molecular biological markers ribonucleic acid review |
| title | MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| title_full | MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| title_fullStr | MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| title_full_unstemmed | MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| title_short | MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| title_sort | micrornas as molecular biological markers of benign hyperplasia and prostate cancer differentiation |
| topic | mirna benign prostatic hyperplasia prostate cancer lower urinary tract symptoms prostate specific antigen molecular biological markers ribonucleic acid review |
| url | https://www.urovest.ru/jour/article/view/760 |
| work_keys_str_mv | AT zmakhokhov micrornasasmolecularbiologicalmarkersofbenignhyperplasiaandprostatecancerdifferentiation AT rsismailov micrornasasmolecularbiologicalmarkersofbenignhyperplasiaandprostatecancerdifferentiation AT mikogan micrornasasmolecularbiologicalmarkersofbenignhyperplasiaandprostatecancerdifferentiation |