APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder

APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder

Metabolites of the Amyloid-β precursor protein (APP) proteolysis may underlie brain overgrowth in Autism Spectrum Disorder (ASD). We have found elevated APP metabolites (total APP, secreted (s) APPα, and α-secretase adamalysins in the plasma and brain tissue of children with ASD). In this review, we...

Full description

Bibliographic Details
Main Authors:	Deborah K. Sokol, Debomoy K. Lahiri
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	ASD macrocephaly amyloid precursor protein adamalysins brain development overgrowth
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1201744/full

Similar Items

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly
by: Deborah K. Sokol, et al.
Published: (2023-09-01)

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway
by: Debomoy K Lahiri, et al.
Published: (2013-06-01)

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)
by: Lahiri Debomoy K, et al.
Published: (2013-01-01)

Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker.
by: Balmiki Ray, et al.
Published: (2011-01-01)

Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly
by: Hande Kaymakcalan, et al.
Published: (2021-08-01)

Macrocephaly and Risk of Seizures
by: J Gordon Millichap
Published: (2003-04-01)

Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells.
by: Mythily Srinivasan, et al.
Published: (2016-01-01)

Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation
by: Ruizhi Wang, et al.
Published: (2022-02-01)

Differing prevalence of microcephaly and macrocephaly in male and female fetuses
by: Amalia M. Brawley, et al.
Published: (2023-02-01)

Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay
by: Marcella Zollino, et al.
Published: (2019-08-01)

Long-Term Outcome of Idiopathic Macrocephaly
by: J Gordon Millichap
Published: (2006-11-01)

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures
by: Felipe P. Perez, et al.
Published: (2021-01-01)

Specific Medical Conditions are Associated with Unique Behavioral Profiles in Autism Spectrum Disorders
by: Ditza A. Zachor, et al.
Published: (2016-09-01)

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
by: Vladimir Rudajev, et al.
Published: (2023-09-01)

Amyloid precursor protein : a practical approach /
by: Xia, Weiming, et al.
Published: (2005)

Corrigendum: Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool
by: Ksenija Zega, et al.
Published: (2018-02-01)

Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool
by: Ksenija Zega, et al.
Published: (2017-11-01)

MICROCEPHALY AND MACROCEPHALY. A STUDY ON ANTHROPOMETRIC AND CLINICAL DATA FROM 308 SUBJECTS
by: Ettore Piro
Published: (2019-11-01)

Neuronal subset-specific Pten-deficient mice do not exhibit deficits in sensorimotor gating processes [version 4; peer review: 1 approved, 2 approved with reservations]
by: Matthew S. Binder, et al.
Published: (2025-01-01)

Neuronal subset-specific Pten-deficient mice do not exhibit deficits in sensorimotor gating processes [version 3; peer review: 1 approved, 2 approved with reservations]
by: Matthew S. Binder, et al.
Published: (2020-04-01)

Fetal Macrocephaly: A Novel Sonographic Finding in Congenital Myotonic Dystrophy
by: Shiri Shinar, et al.
Published: (2020-07-01)

Urinary carboxylic acids (UCAs) in subjects with autism spectrum disorder and their association with bacterial overgrowth
by: Gątarek Paulina, et al.
Published: (2020-09-01)

Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism
by: Kit San Yeung, et al.
Published: (2017-12-01)

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption
by: Zachary A. Rodd, et al.
Published: (2023-04-01)

Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation
by: Emily Witek, et al.
Published: (2019-01-01)

Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons.
by: Jason A Bailey, et al.
Published: (2011-01-01)

Small GTPases control macropinocytosis of amyloid precursor protein and cleavage to amyloid-β
by: Justin Chiu, et al.
Published: (2024-05-01)

Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons
by: Kenji Yamamoto, et al.
Published: (2021-06-01)

Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
by: Felipe P. Perez, et al.
Published: (2022-06-01)

Clinical factors associated with need for neurosurgical care in young children with imaging for macrocephaly: a case control study
by: Jessica F. Rohde, et al.
Published: (2023-11-01)

Genetic and clinical approach to macrocephaly: a 5-year single-center study
by: Muhsin Elmas, et al.
Published: (2020-12-01)

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
by: Caroline Evrard, et al.
Published: (2018-11-01)

Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production
by: Ayesha Khan, et al.
Published: (2023-10-01)

Role of Drosophila Amyloid Precursor Protein in Memory Formation
by: Thomas Preat, et al.
Published: (2016-12-01)

Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer’s disease
by: Xiaonan Wang, et al.
Published: (2016-04-01)

Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimers disease
by: Xiaonan Wang, et al.
Published: (2016-03-01)

Secretases Related to Amyloid Precursor Protein Processing
by: Xiaoling Liu, et al.
Published: (2021-12-01)

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease
by: Vladimir Volloch, et al.
Published: (2018-06-01)

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology
by: Grant Pfundstein, et al.
Published: (2022-07-01)

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β
by: Jerome Garcia, et al.
Published: (2022-09-01)