The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis

Abstract Background Age-related macular degeneration (AMD) is a multifactorial chronic disease of the eye. Several candidate pathways have been hypothesized to play a role in AMD pathogenesis. Our work and those of others suggests inflammasome activity as a mechanism associated with retinal pigment...

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Bibliographic Details
Main Authors: Jiangyuan Gao, Jing Z. Cui, Aikun Wang, Hao Hang Rachel Chen, Alison Fong, Joanne A. Matsubara
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Neuroinflammation
Subjects:
Age-related macular degeneration
XIAP
Caspase-1
Inflammasome
Pyroptosis
And retinal pigment epithelium
Online Access:http://link.springer.com/article/10.1186/s12974-019-1558-5

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