Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis
ABSTRACT Background Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. Materials and Methods PubMed, Med...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2023-06-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000300281&lng=en&tlng=en |
| _version_ | 1797810370275966976 |
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| author | Daoqi Wang Jiahong Tan Erkang Geng Chuanping Wan Jinming Xu Bin Yang Yuan Zhou Guiming Zhou Zhenni Ye Jiongming Li Jianhe Liu |
| author_facet | Daoqi Wang Jiahong Tan Erkang Geng Chuanping Wan Jinming Xu Bin Yang Yuan Zhou Guiming Zhou Zhenni Ye Jiongming Li Jianhe Liu |
| author_sort | Daoqi Wang |
| collection | DOAJ |
| description | ABSTRACT Background Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. Materials and Methods PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. Results A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. Conclusions The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones. |
| first_indexed | 2024-03-13T07:07:49Z |
| format | Article |
| id | doaj.art-a0d216f3bea44a188a73871af1b63022 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-03-13T07:07:49Z |
| publishDate | 2023-06-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-a0d216f3bea44a188a73871af1b630222023-06-06T07:35:06ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192023-06-0149328129810.1590/s1677-5538.ibju.2022.0587Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysisDaoqi Wanghttps://orcid.org/0000-0002-6098-9477Jiahong TanErkang GengChuanping WanJinming XuBin YangYuan ZhouGuiming ZhouZhenni YeJiongming LiJianhe LiuABSTRACT Background Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis. Materials and Methods PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software. Results A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results. Conclusions The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000300281&lng=en&tlng=enUrinary CalculiBody Mass IndexObesity |
| spellingShingle | Daoqi Wang Jiahong Tan Erkang Geng Chuanping Wan Jinming Xu Bin Yang Yuan Zhou Guiming Zhou Zhenni Ye Jiongming Li Jianhe Liu Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis International Brazilian Journal of Urology Urinary Calculi Body Mass Index Obesity |
| title | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
| title_full | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
| title_fullStr | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
| title_full_unstemmed | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
| title_short | Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis |
| title_sort | impact of body mass index on size and composition of urinary stones a systematic review and meta analysis |
| topic | Urinary Calculi Body Mass Index Obesity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000300281&lng=en&tlng=en |
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