Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress
Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow transcription following DNA repair.
Bibliographic Details
| Main Authors: |
Jérémy Sandoz,
Max Cigrang,
Amélie Zachayus,
Philippe Catez,
Lise-Marie Donnio,
Clèmence Elly,
Jadwiga Nieminuszczy,
Pietro Berico,
Cathy Braun,
Sergey Alekseev,
Jean-Marc Egly,
Wojciech Niedzwiedz,
Giuseppina Giglia-Mari,
Emmanuel Compe,
Frédéric Coin |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2023-01-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-023-35922-5
|
|---|