Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers
Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series...
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MDPI AG
2020-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/3/551 |
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| author | Jie Zhao Xiangqiang Pan Jian Zhu Xiulin Zhu |
| author_facet | Jie Zhao Xiangqiang Pan Jian Zhu Xiulin Zhu |
| author_sort | Jie Zhao |
| collection | DOAJ |
| description | Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H<sub>2</sub>O<sub>2</sub> or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H<sub>2</sub>O<sub>2</sub> or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery. |
| first_indexed | 2024-04-12T06:07:25Z |
| format | Article |
| id | doaj.art-a0d61508ba6746b7933adf37a8c60346 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-12T06:07:25Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
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| series | Polymers |
| spelling | doaj.art-a0d61508ba6746b7933adf37a8c603462022-12-22T03:44:49ZengMDPI AGPolymers2073-43602020-03-0112355110.3390/polym12030551polym12030551Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release CarriersJie Zhao0Xiangqiang Pan1Jian Zhu2Xiulin Zhu3State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, ChinaState and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, ChinaState and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, ChinaState and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, ChinaStimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H<sub>2</sub>O<sub>2</sub> or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H<sub>2</sub>O<sub>2</sub> or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.https://www.mdpi.com/2073-4360/12/3/551polymer gelsredox responseaggregation-induced emission (aie)fluorescent probesdrug release carriers |
| spellingShingle | Jie Zhao Xiangqiang Pan Jian Zhu Xiulin Zhu Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers Polymers polymer gels redox response aggregation-induced emission (aie) fluorescent probes drug release carriers |
| title | Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers |
| title_full | Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers |
| title_fullStr | Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers |
| title_full_unstemmed | Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers |
| title_short | Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers |
| title_sort | novel aiegen functionalized diselenide crosslinked polymer gels as fluorescent probes and drug release carriers |
| topic | polymer gels redox response aggregation-induced emission (aie) fluorescent probes drug release carriers |
| url | https://www.mdpi.com/2073-4360/12/3/551 |
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