Clinical Potential of Targeting Fibroblast Growth Factor‐23 and αKlotho in the Treatment of Uremic Cardiomyopathy

Clinical Potential of Targeting Fibroblast Growth Factor‐23 and αKlotho in the Treatment of Uremic Cardiomyopathy

Abstract Chronic kidney disease is highly prevalent, affecting 10% to 15% of the adult population worldwide and is associated with increased cardiovascular morbidity and mortality. As chronic kidney disease worsens, a unique cardiovascular phenotype develops characterized by heart muscle disease, in...

Full description

Bibliographic Details
Main Authors:	Jonathan P. Law, Anna M. Price, Luke Pickup, Ashwin Radhakrishnan, Chris Weston, Alan M. Jones, Helen M. McGettrick, Winnie Chua, Richard P. Steeds, Larissa Fabritz, Paulus Kirchhof, Davor Pavlovic, Jonathan N. Townend, Charles J. Ferro
Format:	Article
Language:	English
Published:	Wiley 2020-04-01
Series:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:	αKlotho cardiorenal syndrome FGF23 fibroblast growth factor growth factor kidney
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.120.016041

Similar Items

Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
by: José Alberto Navarro-García, et al.
Published: (2021-11-01)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
by: Ignacio Portales-Castillo, et al.
Published: (2022-09-01)

FGF23 Actions on Target Tissues—With and Without Klotho
by: Beatrice Richter, et al.
Published: (2018-05-01)

Role of sodium‐dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages
by: Ai Hanazaki, et al.
Published: (2020-02-01)

The Saga of Endocrine FGFs
by: Phuc Phan, et al.
Published: (2021-09-01)

The fibroblast growth factor–Klotho axis at molecular level
by: Sun Fuqiang, et al.
Published: (2023-10-01)

Association between Soluble α-Klotho Protein and Metabolic Syndrome in the Adult Population
by: Yung-Wen Cheng, et al.
Published: (2022-01-01)

The importance of whey protein levels of Klotho and fibroblast growth of factor-23 (fgf-23) as early diagnostic markers of chronic kidney damage
by: L. Yu. Milovanova, et al.
Published: (2022-12-01)

Role of sclerostin, fibroblast growth factor-23, and Klotho in hemodialysis patients
by: Azza A I. Elmenyawi, et al.
Published: (2019-01-01)

Fibroblast growth factor-23 (FGF-23) / soluble Klotho protein (sKlotho) / sclerostin glycoprotein ratio disturbance is a novel risk factor for cardiovascular complications in ESRD patients receiving treatment with regular hemodialysis or hemodiafiltration
by: L Yu Milovanova, et al.
Published: (2018-06-01)

The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu
by: Andreja Figurek, et al.
Published: (2021-05-01)

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho
by: Alexandra S. Aaldijk, et al.
Published: (2023-05-01)

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo
by: Ying Li, et al.

Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease
by: Juan Rafael Muñoz-Castañeda, et al.
Published: (2020-03-01)

Serum Klotho in Living Kidney Donors and Kidney Transplant Recipients: A Meta-Analysis
by: Charat Thongprayoon, et al.
Published: (2020-06-01)

Partial Genetic Deletion of Klotho Aggravates Cardiac Calcium Mishandling in Acute Kidney Injury
by: Laura González-Lafuente, et al.
Published: (2023-01-01)

New Insights into the Mechanism of Action of Soluble Klotho
by: George D. Dalton, et al.
Published: (2017-11-01)

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
by: Gérald J. Prud’homme, et al.
Published: (2022-07-01)

Role of the morphogenetic proteins FGF-23 and Klotho and the glycoprotein sclerostin in the assessment of the risk of cardiovascular diseases and the prognosis of chronic kidney disease
by: L Yu Milovanova, et al.
Published: (2015-06-01)

Assessment of Clinical Utility of Assaying FGF-23, Klotho Protein, Osteocalcin, NTX, and Sclerostin in Patients with Primary Hyperparathyroidism
by: Monika Sykała, et al.
Published: (2021-07-01)

Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans
by: A. L. De Sousa-Coelho, et al.
Published: (2023-08-01)

Enfermedad óseo mineral relacionada con la enfermedad renal crónica: Klotho y FGF23; implicaciones cardiovasculares
by: Laura Salanova Villanueva, et al.
Published: (2016-07-01)

Cardiac Rehabilitation Increases Plasma Klotho Levels
by: Ana María Pello Lázaro, et al.
Published: (2024-03-01)

Serum α-Klotho and fibroblast growth factor 23 levels are not associated with non-proliferative diabetic retinopathy in type 1 diabetes mellitus
by: Can Oner, et al.
Published: (2024-02-01)

Correlation of serum soluble Klotho with fibroblast growth factor 23 levels in chronic kidney disease patients; a single centre study
by: Yuvaraj Anand, et al.
Published: (2020-01-01)

Fibroblast growth factor 23 and Klotho protein: assessment of the role in the development of secondary hyperparathyroidism in patients with various stages of chronic kidney disease
by: N.V. Karlovich, et al.
Published: (2021-09-01)

Role of Klotho in Hyperglycemia: Its Levels and Effects on Fibroblast Growth Factor Receptors, Glycolysis, and Glomerular Filtration
by: Marlena Typiak, et al.
Published: (2021-07-01)

Effect of High Intensity Interval Training on the Level of Atrial Fibrillation, Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure
by: Sina Rokhsati, et al.
Published: (2020-07-01)

Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus
by: Esmeralda Castelblanco, et al.
Published: (2022-10-01)

Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
by: Jiao Bi, et al.
Published: (2024-04-01)

Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats
by: Somayeh Kasraei, et al.
Published: (2021-03-01)

Klotho and fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity and their associations with metabolic parameters
by: Anna Socha-Banasiak, et al.
Published: (2020-06-01)

The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23
by: José Alberto Navarro-García, et al.
Published: (2022-01-01)

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice
by: Taylor Landry, et al.
Published: (2021-02-01)

Low Klotho/Fibroblast Growth Factor 23 Ratio Is an Independent Risk Factor for Renal Progression in Chronic Kidney Disease: Finding From KNOW-CKD
by: Hyo Jin Kim, et al.
Published: (2022-07-01)

Topical fibroblast growth factor‐2 for treatment of chronic tympanic membrane perforations
by: Felipe Santos, et al.
Published: (2020-08-01)

Assessment of the relationship between serum soluble Klotho and carotid intima–media thickness and left ventricular dysfunction in hemodialysis patients
by: Emad Abdallah, et al.
Published: (2016-03-01)

Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice
by: Hsuan-Miao Liu, et al.
Published: (2023-11-01)

The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It
by: Jesús Devesa
Published: (2021-03-01)

The Role of Soluble α-klotho Protein in Acromegaly
by: Oana PINZARIU, et al.
Published: (2023-03-01)