Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study
Background: Immune thrombocytopenia purpura (ITP) is one of the most common autoimmune diseases in children characterized by a decreased number of circulating platelets combined with impaired platelet production. There is limited literature data on the prevalence and treatment modalities, and outcom...
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| Format: | Article |
| Language: | English |
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Ital Publication
2022-12-01
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| Series: | SciMedicine Journal |
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| Online Access: | https://www.scimedjournal.org/index.php/SMJ/article/view/469 |
| _version_ | 1797743186035081216 |
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| author | Hassan K. Khalife Fadi Abdel-Sater Zaynab Fatfat Hussein Khalife Kawthar H. Sharaf Al-Deen Hala Khalife |
| author_facet | Hassan K. Khalife Fadi Abdel-Sater Zaynab Fatfat Hussein Khalife Kawthar H. Sharaf Al-Deen Hala Khalife |
| author_sort | Hassan K. Khalife |
| collection | DOAJ |
| description | Background: Immune thrombocytopenia purpura (ITP) is one of the most common autoimmune diseases in children characterized by a decreased number of circulating platelets combined with impaired platelet production. There is limited literature data on the prevalence and treatment modalities, and outcome of ITP in children from Lebanon. Methods: We retrospectively reviewed the demographic and clinical data of 59 patients aged 0–18 years diagnosed with ITP between January 2007 and April 2016 in different hospitals in Beirut and the south of Lebanon. Results: ITP patients represented 2.5% of the total number of children admitted to these hospitals during this period. Among the ITP children, 55.93% were male and 44.07% were female. The greatest number of ITP children were in the 1–4 year group, followed by the 5–9 year group. As for the clinical course of the disease, 40.68% of the ITP children presented acute ITP, whereas 59.32% presented chronic ITP. Among the different therapeutic approaches adopted to treat these ITP children, intravenous immunoglobulin was the most commonly used, followed by steroids, a combination of these both agents, cyclosporine, and splenectomy. Interestingly, these therapeutic modalities induced a statistically significant increase in the patients’ platelet count. In addition, the clinical course of ITP was not significantly associated with each of the age group, the platelet count at diagnosis, and gender of patients. Conclusion:This study showed the prevalence of ITP among children from Lebanon, where more than half of ITP children presented a chronic disease. Further studies are needed to evaluate additional predictors of chronic ITP among children from Lebanon and help medical providers make informed decisions about treating childhood ITP.
Doi: 10.28991/SciMedJ-2022-04-04-02
Full Text: PDF |
| first_indexed | 2024-03-12T14:51:54Z |
| format | Article |
| id | doaj.art-a0dbe182953741f788f8e49006b2c536 |
| institution | Directory Open Access Journal |
| issn | 2704-9833 |
| language | English |
| last_indexed | 2024-03-12T14:51:54Z |
| publishDate | 2022-12-01 |
| publisher | Ital Publication |
| record_format | Article |
| series | SciMedicine Journal |
| spelling | doaj.art-a0dbe182953741f788f8e49006b2c5362023-08-15T09:15:17ZengItal PublicationSciMedicine Journal2704-98332022-12-014415516110.28991/SciMedJ-2022-04-04-02122Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective StudyHassan K. Khalife0Fadi Abdel-Sater1Zaynab Fatfat2Hussein Khalife3Kawthar H. Sharaf Al-Deen4Hala Khalife5Faculty of Medicine, Lebanese University, Beirut,Molecular Immunology Laboratory, Faculty of Sciences(I), Lebanese University, Beirut,Biology department, American University of Beirut, Beirut,Khalifeh Advanced Medical Center, Beirut,Biology Department, Faculty of Sciences (I), Lebanese University, Beirut,6) Rammal Rammal Laboratory (ATAC Group), Faculty of Sciences (I), Lebanese University, 1003 Beirut, Lebanon. 7) School of Pharmacy, University of Camerino, 62032 Camerino,Background: Immune thrombocytopenia purpura (ITP) is one of the most common autoimmune diseases in children characterized by a decreased number of circulating platelets combined with impaired platelet production. There is limited literature data on the prevalence and treatment modalities, and outcome of ITP in children from Lebanon. Methods: We retrospectively reviewed the demographic and clinical data of 59 patients aged 0–18 years diagnosed with ITP between January 2007 and April 2016 in different hospitals in Beirut and the south of Lebanon. Results: ITP patients represented 2.5% of the total number of children admitted to these hospitals during this period. Among the ITP children, 55.93% were male and 44.07% were female. The greatest number of ITP children were in the 1–4 year group, followed by the 5–9 year group. As for the clinical course of the disease, 40.68% of the ITP children presented acute ITP, whereas 59.32% presented chronic ITP. Among the different therapeutic approaches adopted to treat these ITP children, intravenous immunoglobulin was the most commonly used, followed by steroids, a combination of these both agents, cyclosporine, and splenectomy. Interestingly, these therapeutic modalities induced a statistically significant increase in the patients’ platelet count. In addition, the clinical course of ITP was not significantly associated with each of the age group, the platelet count at diagnosis, and gender of patients. Conclusion:This study showed the prevalence of ITP among children from Lebanon, where more than half of ITP children presented a chronic disease. Further studies are needed to evaluate additional predictors of chronic ITP among children from Lebanon and help medical providers make informed decisions about treating childhood ITP. Doi: 10.28991/SciMedJ-2022-04-04-02 Full Text: PDFhttps://www.scimedjournal.org/index.php/SMJ/article/view/469immune thrombocytopenia purpurachildrenlebanontreatment. |
| spellingShingle | Hassan K. Khalife Fadi Abdel-Sater Zaynab Fatfat Hussein Khalife Kawthar H. Sharaf Al-Deen Hala Khalife Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study SciMedicine Journal immune thrombocytopenia purpura children lebanon treatment. |
| title | Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study |
| title_full | Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study |
| title_fullStr | Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study |
| title_full_unstemmed | Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study |
| title_short | Immune Thrombocytopenia Purpura in Children in Lebanon: Prevalence, Treatment Modalities, and Clinical Outcomes in a Retrospective Study |
| title_sort | immune thrombocytopenia purpura in children in lebanon prevalence treatment modalities and clinical outcomes in a retrospective study |
| topic | immune thrombocytopenia purpura children lebanon treatment. |
| url | https://www.scimedjournal.org/index.php/SMJ/article/view/469 |
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