Genomic Profiling Reveals Novel Predictive Biomarkers for Chemo-Radiotherapy Efficacy and Thoracic Toxicity in Non-Small-Cell Lung Cancer

Genomic Profiling Reveals Novel Predictive Biomarkers for Chemo-Radiotherapy Efficacy and Thoracic Toxicity in Non-Small-Cell Lung Cancer

Chemo-radiotherapy (CRT) remains the main treatment modality for non-small-cell lung cancer (NSCLC). However, its clinical efficacy is largely limited by individual variations in radio-sensitivity and radiotherapy-associated toxicity. There is an urgent need to identify genetic determinants that can...

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Bibliographic Details
Main Authors: Kewen He, Shaotong Zhang, Jiaohui Pang, Jiani C. Yin, Dianbin Mu, Jun Wang, Hong Ge, Jie Ma, Zhe Yang, Xiaoli Zheng, Lihua Dong, Junli Zhang, Pengyu Chang, Li Li, Shanshan Tang, Hua Bao, Xue Wu, Xiaonan Wang, Yang Shao, Jinming Yu, Shuanghu Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
radiotherapy
radiation sensitivity
biomarker
genetic variation
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.928605/full

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