Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties
In this paper, a new formulation of biodegradable and bioresorbable chitosan-based hydrogel for controlled drug release was investigated. A chitosan–dendrimer–hydroxyapatite hydrogel, obtained by covalently grafting chitosan powder with an hyperbranched PAMAM dendrimer followed by in-situ precipitat...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/4/754 |
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| author | Alessandro Pistone Daniela Iannazzo Consuelo Celesti Cristina Scolaro Salvatore V. Giofré Roberto Romeo Annamaria Visco |
| author_facet | Alessandro Pistone Daniela Iannazzo Consuelo Celesti Cristina Scolaro Salvatore V. Giofré Roberto Romeo Annamaria Visco |
| author_sort | Alessandro Pistone |
| collection | DOAJ |
| description | In this paper, a new formulation of biodegradable and bioresorbable chitosan-based hydrogel for controlled drug release was investigated. A chitosan–dendrimer–hydroxyapatite hydrogel, obtained by covalently grafting chitosan powder with an hyperbranched PAMAM dendrimer followed by in-situ precipitation of hydroxyapatite and gelification, was synthesized and characterized by FTIR, NMR, TGA, XRD and rheological studies. The hydrogels have been also doped with an anti-inflammatory drug (ketoprofen) in order to investigate their drug release properties. Chemical and chemical-physical characterizations confirmed the successful covalent functionalization of chitosan with PAMAM and the synthesis of nanostructured hydroxyapatite. The developed hydrogel made it possible to obtain an innovative system with tunable rheological and drug-releasing properties relative to the well-known formulation containing chitosan and hydroxyapatite powder. The developed hydrogel showed different rheological and drug-releasing properties of chitosan matrix mixed with hydroxyapatite as a function of dendrimer molecular weight; therefore, the chitosan–dendrimer–hydroxyapatite hydrogel can couple the well-known osteoconductive properties of hydroxyapatite with the drug-release behavior and good processability of chitosan–dendrimer hydrogels, opening new approaches in the field of tissue engineering based on biopolymeric scaffolds. |
| first_indexed | 2024-03-09T06:17:58Z |
| format | Article |
| id | doaj.art-a0dddb5db11d4702a8544d25d8589da5 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T06:17:58Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-a0dddb5db11d4702a8544d25d8589da52023-12-03T11:51:36ZengMDPI AGPolymers2073-43602020-03-0112475410.3390/polym12040754Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological PropertiesAlessandro Pistone0Daniela Iannazzo1Consuelo Celesti2Cristina Scolaro3Salvatore V. Giofré4Roberto Romeo5Annamaria Visco6Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, I-98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, I-98168 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, ItalyIn this paper, a new formulation of biodegradable and bioresorbable chitosan-based hydrogel for controlled drug release was investigated. A chitosan–dendrimer–hydroxyapatite hydrogel, obtained by covalently grafting chitosan powder with an hyperbranched PAMAM dendrimer followed by in-situ precipitation of hydroxyapatite and gelification, was synthesized and characterized by FTIR, NMR, TGA, XRD and rheological studies. The hydrogels have been also doped with an anti-inflammatory drug (ketoprofen) in order to investigate their drug release properties. Chemical and chemical-physical characterizations confirmed the successful covalent functionalization of chitosan with PAMAM and the synthesis of nanostructured hydroxyapatite. The developed hydrogel made it possible to obtain an innovative system with tunable rheological and drug-releasing properties relative to the well-known formulation containing chitosan and hydroxyapatite powder. The developed hydrogel showed different rheological and drug-releasing properties of chitosan matrix mixed with hydroxyapatite as a function of dendrimer molecular weight; therefore, the chitosan–dendrimer–hydroxyapatite hydrogel can couple the well-known osteoconductive properties of hydroxyapatite with the drug-release behavior and good processability of chitosan–dendrimer hydrogels, opening new approaches in the field of tissue engineering based on biopolymeric scaffolds.https://www.mdpi.com/2073-4360/12/4/754chitosantissue engineeringhydroxyapatitePAMAM dendrimerrheological properties |
| spellingShingle | Alessandro Pistone Daniela Iannazzo Consuelo Celesti Cristina Scolaro Salvatore V. Giofré Roberto Romeo Annamaria Visco Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties Polymers chitosan tissue engineering hydroxyapatite PAMAM dendrimer rheological properties |
| title | Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties |
| title_full | Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties |
| title_fullStr | Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties |
| title_full_unstemmed | Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties |
| title_short | Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties |
| title_sort | chitosan pamam hydroxyapatite engineered drug release hydrogels with tunable rheological properties |
| topic | chitosan tissue engineering hydroxyapatite PAMAM dendrimer rheological properties |
| url | https://www.mdpi.com/2073-4360/12/4/754 |
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