Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result
Abstract Background Resistance training has been recommended as an effective measure against age-related loss of muscle mass and muscle strength, called sarcopenia, even in older adults. However, despite subjecting each participant to the same training program, the training effect solely depended on...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-021-02403-7 |
| _version_ | 1831583749477761024 |
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| author | Shuji Sawada Hayao Ozaki Toshiharu Natsume Daiki Nakano Pengyu Deng Toshinori Yoshihara Takuya Osawa Hiroyuki Kobayashi Shuichi Machida Hisashi Naito |
| author_facet | Shuji Sawada Hayao Ozaki Toshiharu Natsume Daiki Nakano Pengyu Deng Toshinori Yoshihara Takuya Osawa Hiroyuki Kobayashi Shuichi Machida Hisashi Naito |
| author_sort | Shuji Sawada |
| collection | DOAJ |
| description | Abstract Background Resistance training has been recommended as an effective measure against age-related loss of muscle mass and muscle strength, called sarcopenia, even in older adults. However, despite subjecting each participant to the same training program, the training effect solely depended on the individual. This study aimed to evaluate whether certain blood parameters influenced the effect of a low-load resistance training program on muscle thickness in the community-dwelling elderly population. Methods Sixty-nine community-dwelling Japanese (49 women and 20 men) subjects aged 69.4 ± 6.5 years were included. Low-load resistance training was performed twice a week for 12 weeks. Muscle thickness at the anterior aspects of the thigh (AT) was measured using a B-mode ultrasound device, and 22 blood parameter levels were assessed before and after the program. We checked the first quartile value of each parameter to establish cutoff values, and participants were divided into low or normal groups for each parameter. Results A low-load resistance training program significantly increased muscle thickness at the AT. The interaction between time and groups was examined at low (< 4.1 g/dL) versus normal (≥ 4.1 g/dL) serum albumin (Alb) levels. Although there was no difference in muscle thickness at the AT before the training intervention, the hypertrophic effects were higher in the normal serum Alb level group than in the low serum Alb level group. The binomial logistic regression analysis showed that participants in the low serum Alb group had an odds ratio of 7.08 for decreased muscle thickness at the AT. The effect of a low-load resistance training program on lower limb muscle thickness appears to be limited in participants with low serum Alb levels before training interventions. Conclusions Serum Alb level may act as a biomarker to predict the effects of low-load resistance training programs on muscle hypertrophy in elderly individuals. Trial registration This study was retrospectively registered in UMIN-Clinical Trial Registry (CTR), ID: UMIN000042759 (date of registration, 14 Dec 2020). |
| first_indexed | 2024-12-17T20:47:41Z |
| format | Article |
| id | doaj.art-a0dde033a9594f9e95e62cea91dc7569 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-17T20:47:41Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-a0dde033a9594f9e95e62cea91dc75692022-12-21T21:33:07ZengBMCBMC Geriatrics1471-23182021-08-012111910.1186/s12877-021-02403-7Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study resultShuji Sawada0Hayao Ozaki1Toshiharu Natsume2Daiki Nakano3Pengyu Deng4Toshinori Yoshihara5Takuya Osawa6Hiroyuki Kobayashi7Shuichi Machida8Hisashi Naito9COI Project Center, Juntendo UniversitySchool of Health and Sports Science, Juntendo UniversityCOI Project Center, Juntendo UniversityRitsumeikan Global Innovation Research Organization, Ritsumeikan UniversitySchool of Health and Sports Science, Juntendo UniversitySchool of Health and Sports Science, Juntendo UniversityCOI Project Center, Juntendo UniversityDepartment of Internal Medicine, Mito Kyodo General Hospital, University of TsukubaCOI Project Center, Juntendo UniversityCOI Project Center, Juntendo UniversityAbstract Background Resistance training has been recommended as an effective measure against age-related loss of muscle mass and muscle strength, called sarcopenia, even in older adults. However, despite subjecting each participant to the same training program, the training effect solely depended on the individual. This study aimed to evaluate whether certain blood parameters influenced the effect of a low-load resistance training program on muscle thickness in the community-dwelling elderly population. Methods Sixty-nine community-dwelling Japanese (49 women and 20 men) subjects aged 69.4 ± 6.5 years were included. Low-load resistance training was performed twice a week for 12 weeks. Muscle thickness at the anterior aspects of the thigh (AT) was measured using a B-mode ultrasound device, and 22 blood parameter levels were assessed before and after the program. We checked the first quartile value of each parameter to establish cutoff values, and participants were divided into low or normal groups for each parameter. Results A low-load resistance training program significantly increased muscle thickness at the AT. The interaction between time and groups was examined at low (< 4.1 g/dL) versus normal (≥ 4.1 g/dL) serum albumin (Alb) levels. Although there was no difference in muscle thickness at the AT before the training intervention, the hypertrophic effects were higher in the normal serum Alb level group than in the low serum Alb level group. The binomial logistic regression analysis showed that participants in the low serum Alb group had an odds ratio of 7.08 for decreased muscle thickness at the AT. The effect of a low-load resistance training program on lower limb muscle thickness appears to be limited in participants with low serum Alb levels before training interventions. Conclusions Serum Alb level may act as a biomarker to predict the effects of low-load resistance training programs on muscle hypertrophy in elderly individuals. Trial registration This study was retrospectively registered in UMIN-Clinical Trial Registry (CTR), ID: UMIN000042759 (date of registration, 14 Dec 2020).https://doi.org/10.1186/s12877-021-02403-7AgedResistance trainingSerum albuminMuscle hypertrophy |
| spellingShingle | Shuji Sawada Hayao Ozaki Toshiharu Natsume Daiki Nakano Pengyu Deng Toshinori Yoshihara Takuya Osawa Hiroyuki Kobayashi Shuichi Machida Hisashi Naito Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result BMC Geriatrics Aged Resistance training Serum albumin Muscle hypertrophy |
| title | Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result |
| title_full | Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result |
| title_fullStr | Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result |
| title_full_unstemmed | Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result |
| title_short | Serum albumin levels as a predictive biomarker for low-load resistance training programs’ effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result |
| title_sort | serum albumin levels as a predictive biomarker for low load resistance training programs effects on muscle thickness in the community dwelling elderly japanese population interventional study result |
| topic | Aged Resistance training Serum albumin Muscle hypertrophy |
| url | https://doi.org/10.1186/s12877-021-02403-7 |
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