IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

ABSTRACT Streptococcus pneumoniae is a leading bacterial cause of a wide range of infections, and pneumococcal pneumosepsis causes high mortality in hosts infected with antibiotic-resistant strains and those who cannot resolve ongoing inflammation. The factors which influence the development and out...

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Bibliographic Details
Main Authors: Xuemei Gou, Wenchun Xu, Yusi Liu, Yang Peng, Wenlong Xu, Yibing Yin, Xuemei Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
IL-6
macrophage
inflammation
pyroptosis
pneumococcal pneumosepsis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02049-21

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