Post-modification of PLLA nanofiber nonwovens by various solvent treatments
Degradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been developed. In order to tailor the material for specific applica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2023-1124 |
| _version_ | 1797646322858196992 |
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| author | Götz Andreas Reske Thomas Oschatz Stefan Grabow Niels Illner Sabine |
| author_facet | Götz Andreas Reske Thomas Oschatz Stefan Grabow Niels Illner Sabine |
| author_sort | Götz Andreas |
| collection | DOAJ |
| description | Degradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been developed. In order to tailor the material for specific applications, dedicated fine-tuning procedures are required. To modify fiber interconnection or porosity, solvents or their dilutions are applicable. In this work, the effect of differently diluted protic and aprotic-polar solvents on electrospun poly-L-lactic acid (PLLA) nonwovens was investigated via immersion or vapor exposure. Fiber adhesion was observed with protic solvents. Fiber destruction and increased polymer crystallinity was observed with aprotic polar solvents. The immersion duration revealed to be far more irrelevant than solvent dilution. None of the tested solvents affected molecular weight. This opens up significant research potential to replace halogenated solvents as a cornerstone of eco-friendly “green” electrospinning processes. The results of this study are suggesting that biomaterials with desired properties can be produced in a targeted manner. |
| first_indexed | 2024-03-11T15:01:01Z |
| format | Article |
| id | doaj.art-a0e028ad5c1a4f288931e98eefd16949 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-11T15:01:01Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-a0e028ad5c1a4f288931e98eefd169492023-10-30T07:58:12ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042023-09-019149549810.1515/cdbme-2023-1124Post-modification of PLLA nanofiber nonwovens by various solvent treatmentsGötz Andreas0Reske Thomas1Oschatz Stefan2Grabow Niels3Illner Sabine4Institute for Biomedical Engineering, University Medical Center Rostock, Friedrich- Barnewitz-Str. 4, 18119Rostock, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Rostock, GermanyInstitute for Biomedical Engineering, University Medical Center Rostock, Rostock, GermanyInstitute for Biomedical Engineering, University Medical Center Rostock, Rostock, GermanyInstitute for Biomedical Engineering, University Medical Center Rostock, Rostock, GermanyDegradable polymeric Biomaterials, such as polylactic acid, are widely used in medical field as bioresorbable implant coatings. More recently, stent covers, implantable tubes or wound dressings made from electrospun nanofibers have been developed. In order to tailor the material for specific applications, dedicated fine-tuning procedures are required. To modify fiber interconnection or porosity, solvents or their dilutions are applicable. In this work, the effect of differently diluted protic and aprotic-polar solvents on electrospun poly-L-lactic acid (PLLA) nonwovens was investigated via immersion or vapor exposure. Fiber adhesion was observed with protic solvents. Fiber destruction and increased polymer crystallinity was observed with aprotic polar solvents. The immersion duration revealed to be far more irrelevant than solvent dilution. None of the tested solvents affected molecular weight. This opens up significant research potential to replace halogenated solvents as a cornerstone of eco-friendly “green” electrospinning processes. The results of this study are suggesting that biomaterials with desired properties can be produced in a targeted manner.https://doi.org/10.1515/cdbme-2023-1124fiber interconnectionsolvent influencetailored morphology |
| spellingShingle | Götz Andreas Reske Thomas Oschatz Stefan Grabow Niels Illner Sabine Post-modification of PLLA nanofiber nonwovens by various solvent treatments Current Directions in Biomedical Engineering fiber interconnection solvent influence tailored morphology |
| title | Post-modification of PLLA nanofiber nonwovens by various solvent treatments |
| title_full | Post-modification of PLLA nanofiber nonwovens by various solvent treatments |
| title_fullStr | Post-modification of PLLA nanofiber nonwovens by various solvent treatments |
| title_full_unstemmed | Post-modification of PLLA nanofiber nonwovens by various solvent treatments |
| title_short | Post-modification of PLLA nanofiber nonwovens by various solvent treatments |
| title_sort | post modification of plla nanofiber nonwovens by various solvent treatments |
| topic | fiber interconnection solvent influence tailored morphology |
| url | https://doi.org/10.1515/cdbme-2023-1124 |
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