Biocompatibility in vivo of elastic cartilage treated in alkaline solutions
ABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous impla...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Minas Gerais
2022-04-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011&tlng=en |
| _version_ | 1818274825491185664 |
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| author | D.P. Araújo G.H.M. Araujo L.P. Oliveira L.B.M. Leite V.S. Franzo G.P. Santos T.R. Souza V.A.S. Vulcani |
| author_facet | D.P. Araújo G.H.M. Araujo L.P. Oliveira L.B.M. Leite V.S. Franzo G.P. Santos T.R. Souza V.A.S. Vulcani |
| author_sort | D.P. Araújo |
| collection | DOAJ |
| description | ABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous implants of cartilage treated in alkaline solution and the control group (CG) receiving subcutaneous implants of untreated cartilage. In both groups, the implants were removed on days 3, 7, 14, 21 and 42 with the preparation of histological slides stained with Hematoxylin and Eosin for the quantification of inflammatory cells, fibroblasts, angiogenesis, and cartilage degradation. The results showed that EG presented a less intense inflammatory infiltrate and better organization of collagen fibers compared to CG. It was concluded that the alkaline treatment provided better biocompatibility for elastic cartilage when implanted subcutaneously in rats. |
| first_indexed | 2024-12-12T22:20:01Z |
| format | Article |
| id | doaj.art-a0e07aa3166b485a83797985160a876f |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-12-12T22:20:01Z |
| publishDate | 2022-04-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-a0e07aa3166b485a83797985160a876f2022-12-22T00:09:57ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622022-04-01741112010.1590/1678-4162-12435Biocompatibility in vivo of elastic cartilage treated in alkaline solutionsD.P. Araújohttps://orcid.org/0000-0003-0986-6890G.H.M. Araujohttps://orcid.org/0000-0002-8991-7725L.P. Oliveirahttps://orcid.org/0000-0002-4728-0674L.B.M. Leitehttps://orcid.org/0000-0003-4237-6279V.S. Franzohttps://orcid.org/0000-0001-9957-8942G.P. Santoshttps://orcid.org/0000-0003-0230-0579T.R. Souzahttps://orcid.org/0000-0002-4428-1591V.A.S. Vulcanihttps://orcid.org/0000-0001-5968-330XABSTRACT This study verified the in vivo biocompatibility of bovine elastic cartilage decellularized with alkaline solution in relation to the non-decellularized cartilage implanted in rats. Fifty Wistar rats were divided into two groups, with the experimental group (EG) receiving subcutaneous implants of cartilage treated in alkaline solution and the control group (CG) receiving subcutaneous implants of untreated cartilage. In both groups, the implants were removed on days 3, 7, 14, 21 and 42 with the preparation of histological slides stained with Hematoxylin and Eosin for the quantification of inflammatory cells, fibroblasts, angiogenesis, and cartilage degradation. The results showed that EG presented a less intense inflammatory infiltrate and better organization of collagen fibers compared to CG. It was concluded that the alkaline treatment provided better biocompatibility for elastic cartilage when implanted subcutaneously in rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011&tlng=enalkaline solutionbiomaterialcartilageand collagen |
| spellingShingle | D.P. Araújo G.H.M. Araujo L.P. Oliveira L.B.M. Leite V.S. Franzo G.P. Santos T.R. Souza V.A.S. Vulcani Biocompatibility in vivo of elastic cartilage treated in alkaline solutions Arquivo Brasileiro de Medicina Veterinária e Zootecnia alkaline solution biomaterial cartilage and collagen |
| title | Biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| title_full | Biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| title_fullStr | Biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| title_full_unstemmed | Biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| title_short | Biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| title_sort | biocompatibility in vivo of elastic cartilage treated in alkaline solutions |
| topic | alkaline solution biomaterial cartilage and collagen |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000100011&tlng=en |
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