Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients
Peritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD). Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis. This study included six patients receiving CAPD treated with sulodexide at the do...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=6;spage=1194;epage=1199;aulast=Guedri |
| _version_ | 1819095141953044480 |
|---|---|
| author | Yosra Guedri K Najla Damma Melek Toumi Wissal Sahtout Awatef Azzabi Sinda Mrabet Safa Nouira Dalila Saidane Samira Amor Anis Belarbia Dorsaf Zellama Abdellatif Achour |
| author_facet | Yosra Guedri K Najla Damma Melek Toumi Wissal Sahtout Awatef Azzabi Sinda Mrabet Safa Nouira Dalila Saidane Samira Amor Anis Belarbia Dorsaf Zellama Abdellatif Achour |
| author_sort | Yosra Guedri |
| collection | DOAJ |
| description | Peritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD). Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis. This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days. Clinical and biologic parameters were assessed before starting the treatment (D0 and after 10 days of treatment (D10. We also evaluated the benefit of therapy persisting 20 days after the end of treatment (D30. The sulodexide administration produced a significant improvement of the peritoneal function as determined by a significant increase in the following ratios measured at the 4 th h of dwell time on D0 and D30: dialysate-to plasma (D/P) creatinine from 0.63 ± 1.45 to 0.85 ± 0.073 (P = 0.028) and D/P urea from 0.63 ± 0.15 to 79 ± 0.2 (P = 0.048). A significant decrease of albumin leakage was observed, which was 0.90 ± 0.40 g/L at baseline, 0.67 ± 0.36 g/L on the 10 th day, and 0.43 ± 0.22g/L 20 days after the end of treatment. Within 10-day treatment period, use of sulodexide resulted in a reduction in the peritoneal loss of albumin, in addition to improvement of the quality of dialysis and the residual renal function among these patients. |
| first_indexed | 2024-12-21T23:38:35Z |
| format | Article |
| id | doaj.art-a0e08f616ef74a17be9b99ef9ba6913b |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-21T23:38:35Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-a0e08f616ef74a17be9b99ef9ba6913b2022-12-21T18:46:17ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422016-01-0127611941199Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patientsYosra GuedriK Najla DammaMelek ToumiWissal SahtoutAwatef AzzabiSinda MrabetSafa NouiraDalila SaidaneSamira AmorAnis BelarbiaDorsaf ZellamaAbdellatif AchourPeritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD). Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis. This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days. Clinical and biologic parameters were assessed before starting the treatment (D0 and after 10 days of treatment (D10. We also evaluated the benefit of therapy persisting 20 days after the end of treatment (D30. The sulodexide administration produced a significant improvement of the peritoneal function as determined by a significant increase in the following ratios measured at the 4 th h of dwell time on D0 and D30: dialysate-to plasma (D/P) creatinine from 0.63 ± 1.45 to 0.85 ± 0.073 (P = 0.028) and D/P urea from 0.63 ± 0.15 to 79 ± 0.2 (P = 0.048). A significant decrease of albumin leakage was observed, which was 0.90 ± 0.40 g/L at baseline, 0.67 ± 0.36 g/L on the 10 th day, and 0.43 ± 0.22g/L 20 days after the end of treatment. Within 10-day treatment period, use of sulodexide resulted in a reduction in the peritoneal loss of albumin, in addition to improvement of the quality of dialysis and the residual renal function among these patients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=6;spage=1194;epage=1199;aulast=Guedri |
| spellingShingle | Yosra Guedri K Najla Damma Melek Toumi Wissal Sahtout Awatef Azzabi Sinda Mrabet Safa Nouira Dalila Saidane Samira Amor Anis Belarbia Dorsaf Zellama Abdellatif Achour Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients Saudi Journal of Kidney Diseases and Transplantation |
| title | Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| title_full | Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| title_fullStr | Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| title_full_unstemmed | Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| title_short | Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| title_sort | effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=6;spage=1194;epage=1199;aulast=Guedri |
| work_keys_str_mv | AT yosraguedri effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT knajladamma effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT melektoumi effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT wissalsahtout effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT awatefazzabi effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT sindamrabet effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT safanouira effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT dalilasaidane effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT samiraamor effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT anisbelarbia effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT dorsafzellama effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients AT abdellatifachour effectofintraperitonealinjectionofsulodexideonperitonealfunctionandalbuminleakageincontinuousambulatoryperitonealdialysispatients |