Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer
Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to contribute to therapeutic resistance. The present review focuses on the IAP m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1124600/full |
| _version_ | 1811167193416597504 |
|---|---|
| author | Philipp Wolf Philipp Wolf |
| author_facet | Philipp Wolf Philipp Wolf |
| author_sort | Philipp Wolf |
| collection | DOAJ |
| description | Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to contribute to therapeutic resistance. The present review focuses on the IAP members cIAP1, cIAP2, XIAP, Survivin and Livin and their importance as potential therapeutic targets in bladder cancer. |
| first_indexed | 2024-04-10T16:05:03Z |
| format | Article |
| id | doaj.art-a0e1fd90dbb84a41b759c57d8bef3596 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T16:05:03Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a0e1fd90dbb84a41b759c57d8bef35962023-02-10T05:33:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.11246001124600Inhibitor of apoptosis proteins as therapeutic targets in bladder cancerPhilipp Wolf0Philipp Wolf1Department of Urology, Medical Center-University of Freiburg, Freiburg, GermanyFaculty of Medicine, University of Freiburg, Freiburg, GermanyEvasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to contribute to therapeutic resistance. The present review focuses on the IAP members cIAP1, cIAP2, XIAP, Survivin and Livin and their importance as potential therapeutic targets in bladder cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1124600/fullbladder cancerapoptosisinhibitor of apoptosis proteinscIAP1cIAP2XIAP |
| spellingShingle | Philipp Wolf Philipp Wolf Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer Frontiers in Oncology bladder cancer apoptosis inhibitor of apoptosis proteins cIAP1 cIAP2 XIAP |
| title | Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| title_full | Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| title_fullStr | Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| title_full_unstemmed | Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| title_short | Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| title_sort | inhibitor of apoptosis proteins as therapeutic targets in bladder cancer |
| topic | bladder cancer apoptosis inhibitor of apoptosis proteins cIAP1 cIAP2 XIAP |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1124600/full |
| work_keys_str_mv | AT philippwolf inhibitorofapoptosisproteinsastherapeutictargetsinbladdercancer AT philippwolf inhibitorofapoptosisproteinsastherapeutictargetsinbladdercancer |