Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat
The deployment of disease resistance genes is currently the most economical and environmentally sustainable method of crop protection. However, disease resistance genes can rapidly break down because of constant pathogen evolution, particularly when they are deployed singularly. Polygenic resistance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2023.1223504/full |
| _version_ | 1797729245467770880 |
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| author | Matthias Jost Megan A. Outram Kathy Dibley Jianping Zhang Ming Luo Michael Ayliffe |
| author_facet | Matthias Jost Megan A. Outram Kathy Dibley Jianping Zhang Ming Luo Michael Ayliffe |
| author_sort | Matthias Jost |
| collection | DOAJ |
| description | The deployment of disease resistance genes is currently the most economical and environmentally sustainable method of crop protection. However, disease resistance genes can rapidly break down because of constant pathogen evolution, particularly when they are deployed singularly. Polygenic resistance is, therefore, considered the most durable, but combining and maintaining these genes by breeding is a laborious process as effective genes are usually unlinked. The deployment of polygenic resistance with single-locus inheritance is a promising innovation that overcomes these difficulties while enhancing resistance durability. Because of major advances in genomic technologies, increasing numbers of plant resistance genes have been cloned, enabling the development of resistance transgene stacks (RTGSs) that encode multiple genes all located at a single genetic locus. Gene stacks encoding five stem rust resistance genes have now been developed in transgenic wheat and offer both breeding simplicity and potential resistance durability. The development of similar genomic resources in phytopathogens has advanced effector gene isolation and, in some instances, enabled functional validation of individual resistance genes in RTGS. Here, the wheat stem rust pathosystem is used as an illustrative example of how host and pathogen genomic advances have been instrumental in the development of RTGS, which is a strategy applicable to many other agricultural crop species. |
| first_indexed | 2024-03-12T11:26:20Z |
| format | Article |
| id | doaj.art-a0e20e5ff7794156a56f14fd80d96c65 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-03-12T11:26:20Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-a0e20e5ff7794156a56f14fd80d96c652023-09-01T08:17:54ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2023-09-011410.3389/fpls.2023.12235041223504Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheatMatthias JostMegan A. OutramKathy DibleyJianping ZhangMing LuoMichael AyliffeThe deployment of disease resistance genes is currently the most economical and environmentally sustainable method of crop protection. However, disease resistance genes can rapidly break down because of constant pathogen evolution, particularly when they are deployed singularly. Polygenic resistance is, therefore, considered the most durable, but combining and maintaining these genes by breeding is a laborious process as effective genes are usually unlinked. The deployment of polygenic resistance with single-locus inheritance is a promising innovation that overcomes these difficulties while enhancing resistance durability. Because of major advances in genomic technologies, increasing numbers of plant resistance genes have been cloned, enabling the development of resistance transgene stacks (RTGSs) that encode multiple genes all located at a single genetic locus. Gene stacks encoding five stem rust resistance genes have now been developed in transgenic wheat and offer both breeding simplicity and potential resistance durability. The development of similar genomic resources in phytopathogens has advanced effector gene isolation and, in some instances, enabled functional validation of individual resistance genes in RTGS. Here, the wheat stem rust pathosystem is used as an illustrative example of how host and pathogen genomic advances have been instrumental in the development of RTGS, which is a strategy applicable to many other agricultural crop species.https://www.frontiersin.org/articles/10.3389/fpls.2023.1223504/fullavirulencedurablepolygenicplantdiseaseresistance |
| spellingShingle | Matthias Jost Megan A. Outram Kathy Dibley Jianping Zhang Ming Luo Michael Ayliffe Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat Frontiers in Plant Science avirulence durable polygenic plant disease resistance |
| title | Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat |
| title_full | Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat |
| title_fullStr | Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat |
| title_full_unstemmed | Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat |
| title_short | Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat |
| title_sort | plant and pathogen genomics essential approaches for stem rust resistance gene stacks in wheat |
| topic | avirulence durable polygenic plant disease resistance |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2023.1223504/full |
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