Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials
(1) Background: Vitamin D supplementation after type 1 diabetes mellitus (T1DM) onset has led to conflicting results on beta-cell preservation. Aim: This paper presents a systematic review to verify whether randomized prospective controlled trials (RCTs) demonstrate that improved vitamin D status co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/7/1042 |
| _version_ | 1797212173289652224 |
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| author | Yuval Dadon Lior Hecht Sagie Francis B. Mimouni Iris Arad Joseph Mendlovic |
| author_facet | Yuval Dadon Lior Hecht Sagie Francis B. Mimouni Iris Arad Joseph Mendlovic |
| author_sort | Yuval Dadon |
| collection | DOAJ |
| description | (1) Background: Vitamin D supplementation after type 1 diabetes mellitus (T1DM) onset has led to conflicting results on beta-cell preservation. Aim: This paper presents a systematic review to verify whether randomized prospective controlled trials (RCTs) demonstrate that improved vitamin D status confers protection on T1DM. (2) Methods: A systematic review was conducted up until 18 January 2024 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching MEDLINE, MEDLINE In-Process, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials, using keywords “vitamin D”, “type 1 diabetes”, and “children”. (3) Results: Following the above-mentioned search process, 408 articles in PubMed and 791 in Embase met inclusion criteria. After removing duplicates, 471 articles remained. After exclusion criteria, 11 RCTs remained. Because of major heterogeneity in design and outcomes, no meta-analyses were conducted, allowing only for qualitative analyses. There was no strong evidence that vitamin D supplementation has lasting effects on beta-cell preservation or glycemic control in new-onset T1DM. (4) Conclusions: More rigorous, larger studies are needed to demonstrate whether vitamin D improves beta-cell preservation or glycemic control in new-onset T1DM. Because T1DM may cause osteopenia, it is advisable that patients with new onset T1DM have adequate vitamin D stores. |
| first_indexed | 2024-04-24T10:38:10Z |
| format | Article |
| id | doaj.art-a0e47b1bda6a4e13b3d139708bb64025 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T10:38:10Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a0e47b1bda6a4e13b3d139708bb640252024-04-12T13:24:27ZengMDPI AGNutrients2072-66432024-04-01167104210.3390/nu16071042Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical TrialsYuval Dadon0Lior Hecht Sagie1Francis B. Mimouni2Iris Arad3Joseph Mendlovic4Ministry of Health, Jerusalem 9101002, IsraelMinistry of Health, Jerusalem 9101002, IsraelLeumit Health Services Research Center, Tel Aviv 6473817, IsraelSchool of Medicine, Hebrew University of Jerusalem, Jerusalem 9190500, IsraelMinistry of Health, Jerusalem 9101002, Israel(1) Background: Vitamin D supplementation after type 1 diabetes mellitus (T1DM) onset has led to conflicting results on beta-cell preservation. Aim: This paper presents a systematic review to verify whether randomized prospective controlled trials (RCTs) demonstrate that improved vitamin D status confers protection on T1DM. (2) Methods: A systematic review was conducted up until 18 January 2024 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching MEDLINE, MEDLINE In-Process, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials, using keywords “vitamin D”, “type 1 diabetes”, and “children”. (3) Results: Following the above-mentioned search process, 408 articles in PubMed and 791 in Embase met inclusion criteria. After removing duplicates, 471 articles remained. After exclusion criteria, 11 RCTs remained. Because of major heterogeneity in design and outcomes, no meta-analyses were conducted, allowing only for qualitative analyses. There was no strong evidence that vitamin D supplementation has lasting effects on beta-cell preservation or glycemic control in new-onset T1DM. (4) Conclusions: More rigorous, larger studies are needed to demonstrate whether vitamin D improves beta-cell preservation or glycemic control in new-onset T1DM. Because T1DM may cause osteopenia, it is advisable that patients with new onset T1DM have adequate vitamin D stores.https://www.mdpi.com/2072-6643/16/7/1042vitamin Dvitamin D metabolitesinsulin-dependent diabetes mellitustype 1 diabetes (T1DM)beta-cell preservationglycemic control |
| spellingShingle | Yuval Dadon Lior Hecht Sagie Francis B. Mimouni Iris Arad Joseph Mendlovic Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials Nutrients vitamin D vitamin D metabolites insulin-dependent diabetes mellitus type 1 diabetes (T1DM) beta-cell preservation glycemic control |
| title | Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials |
| title_full | Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials |
| title_fullStr | Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials |
| title_full_unstemmed | Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials |
| title_short | Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials |
| title_sort | vitamin d and insulin dependent diabetes a systematic review of clinical trials |
| topic | vitamin D vitamin D metabolites insulin-dependent diabetes mellitus type 1 diabetes (T1DM) beta-cell preservation glycemic control |
| url | https://www.mdpi.com/2072-6643/16/7/1042 |
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