Live fast, die soon: cell cycle progression and lifespan in yeast cells
Our understanding of lifespan has benefited enormously from the study of a simple model, the yeast Saccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are conserved in mammalian cells. Nutrient-limiting condi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2015-03-01
|
| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/live-fast-die-soon-cell-cycle-progression-and-lifespan-in-yeast-cells/ |
| _version_ | 1826532052389855232 |
|---|---|
| author | Javier Jiménez Samuel Bru Mariana PC Ribeiro Josep Clotet |
| author_facet | Javier Jiménez Samuel Bru Mariana PC Ribeiro Josep Clotet |
| author_sort | Javier Jiménez |
| collection | DOAJ |
| description | Our understanding of lifespan has benefited enormously from the study of a simple model, the yeast Saccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are conserved in mammalian cells. Nutrient-limiting conditions have been involved in lifespan extension, especially in the case of caloric restriction, which also has a direct impact on cell cycle progression. In fact, other environmental stresses (osmotic, oxidative) that interfere with normal cell cycle progression also influence the lifespan of cells, indicating a relationship between lifespan and cell cycle control. In the present review we compile and discuss new findings related to how cell cycle progression is regulated by other nutrients. We centred this review on the analysis of phosphate, also give some attention to nitrogen, and the impact of these nutrients on lifespan. |
| first_indexed | 2024-12-10T03:32:44Z |
| format | Article |
| id | doaj.art-a0e5111032ba4054ad183ae29e5d0819 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:45:06Z |
| publishDate | 2015-03-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-a0e5111032ba4054ad183ae29e5d08192025-03-12T13:46:41ZengShared Science Publishers OGMicrobial Cell2311-26382015-03-0123626710.15698/mic2015.03.191Live fast, die soon: cell cycle progression and lifespan in yeast cellsJavier Jiménez0Samuel Bru1Mariana PC Ribeiro2Josep Clotet3Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.Our understanding of lifespan has benefited enormously from the study of a simple model, the yeast Saccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are conserved in mammalian cells. Nutrient-limiting conditions have been involved in lifespan extension, especially in the case of caloric restriction, which also has a direct impact on cell cycle progression. In fact, other environmental stresses (osmotic, oxidative) that interfere with normal cell cycle progression also influence the lifespan of cells, indicating a relationship between lifespan and cell cycle control. In the present review we compile and discuss new findings related to how cell cycle progression is regulated by other nutrients. We centred this review on the analysis of phosphate, also give some attention to nitrogen, and the impact of these nutrients on lifespan.http://microbialcell.com/researcharticles/live-fast-die-soon-cell-cycle-progression-and-lifespan-in-yeast-cells/cell cyclelifespanphosphatePho85 |
| spellingShingle | Javier Jiménez Samuel Bru Mariana PC Ribeiro Josep Clotet Live fast, die soon: cell cycle progression and lifespan in yeast cells Microbial Cell cell cycle lifespan phosphate Pho85 |
| title | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| title_full | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| title_fullStr | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| title_full_unstemmed | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| title_short | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| title_sort | live fast die soon cell cycle progression and lifespan in yeast cells |
| topic | cell cycle lifespan phosphate Pho85 |
| url | http://microbialcell.com/researcharticles/live-fast-die-soon-cell-cycle-progression-and-lifespan-in-yeast-cells/ |
| work_keys_str_mv | AT javierjimenez livefastdiesooncellcycleprogressionandlifespaninyeastcells AT samuelbru livefastdiesooncellcycleprogressionandlifespaninyeastcells AT marianapcribeiro livefastdiesooncellcycleprogressionandlifespaninyeastcells AT josepclotet livefastdiesooncellcycleprogressionandlifespaninyeastcells |