Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats
Background & Objective: Many anti stress drugs have a lot of side effects on learning. The aim of this study was to compare the effect of Rosemary plant and Alprazolam on learning under stress conditions in laboratory mice. Materials & Methods: In this experimental study, 60 adult female rat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2018-12-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1475-en.pdf |
| _version_ | 1797679641624838144 |
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| author | Mehrdad Modaresi Masoume Amoorizi |
| author_facet | Mehrdad Modaresi Masoume Amoorizi |
| author_sort | Mehrdad Modaresi |
| collection | DOAJ |
| description | Background & Objective: Many anti stress drugs have a lot of side effects on learning. The aim of this study was to compare the effect of Rosemary plant and Alprazolam on learning under stress conditions in laboratory mice.
Materials & Methods: In this experimental study, 60 adult female rats were used. In order to investigate the learning capacity under stress conditions, the rats were divided into 6 groups of control, stress, alprazolam and the three experimental groups that received the hydro-alcoholic extract of rosemary plants at doses of 50, 100 and 200. In all of the samples (except the control group) 30 minutes after injection, the mice were placed in a dark box for 50 minutes for stress. Subsequently, observational behaviors of the rats were recorded by using mouse maze. The results were analyzed using SPSS software.
Results: The results showed that rosemary hydro alcoholic extract at 100 and 200 mg/kg compared to the stress and alprazolam group significantly decreased the time to reach the target box in the Maze form, which indicates a reduction on effect of stress on the learning, while the number of errors in selecting the target box (reaching the target) at a dose of 200 mg/kg shows a significant decrease with the stress and drug group.
Conclusion: According to the results, effective compounds in rosemary extract in two doses of 100 and 200 mg/kg can increase the learning in these conditions with the effect of reducing stress. |
| first_indexed | 2024-03-11T23:17:46Z |
| format | Article |
| id | doaj.art-a0e6b2159e1a42ebaef3de6b67881b22 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:46Z |
| publishDate | 2018-12-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-a0e6b2159e1a42ebaef3de6b67881b222023-09-20T21:24:38ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232018-12-0183862869Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in RatsMehrdad Modaresi0Masoume Amoorizi1 Background & Objective: Many anti stress drugs have a lot of side effects on learning. The aim of this study was to compare the effect of Rosemary plant and Alprazolam on learning under stress conditions in laboratory mice. Materials & Methods: In this experimental study, 60 adult female rats were used. In order to investigate the learning capacity under stress conditions, the rats were divided into 6 groups of control, stress, alprazolam and the three experimental groups that received the hydro-alcoholic extract of rosemary plants at doses of 50, 100 and 200. In all of the samples (except the control group) 30 minutes after injection, the mice were placed in a dark box for 50 minutes for stress. Subsequently, observational behaviors of the rats were recorded by using mouse maze. The results were analyzed using SPSS software. Results: The results showed that rosemary hydro alcoholic extract at 100 and 200 mg/kg compared to the stress and alprazolam group significantly decreased the time to reach the target box in the Maze form, which indicates a reduction on effect of stress on the learning, while the number of errors in selecting the target box (reaching the target) at a dose of 200 mg/kg shows a significant decrease with the stress and drug group. Conclusion: According to the results, effective compounds in rosemary extract in two doses of 100 and 200 mg/kg can increase the learning in these conditions with the effect of reducing stress.http://jabs.fums.ac.ir/article-1-1475-en.pdfrosemarylearningstressalprazolamt-shaped mazemice |
| spellingShingle | Mehrdad Modaresi Masoume Amoorizi Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats Journal of Advanced Biomedical Sciences rosemary learning stress alprazolam t-shaped maze mice |
| title | Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats |
| title_full | Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats |
| title_fullStr | Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats |
| title_full_unstemmed | Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats |
| title_short | Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats |
| title_sort | effect of hydro alcoholic extract of rosemary in comparison with alprazolam on learning under stress conditions in rats |
| topic | rosemary learning stress alprazolam t-shaped maze mice |
| url | http://jabs.fums.ac.ir/article-1-1475-en.pdf |
| work_keys_str_mv | AT mehrdadmodaresi effectofhydroalcoholicextractofrosemaryincomparisonwithalprazolamonlearningunderstressconditionsinrats AT masoumeamoorizi effectofhydroalcoholicextractofrosemaryincomparisonwithalprazolamonlearningunderstressconditionsinrats |