ASSESSMENT OF α-AMYLASE INHIBITION ACTIVITY BY AN OPTIMIZED AND VALIDATED IN VITRO MICROSCALE METHOD

ASSESSMENT OF α-AMYLASE INHIBITION ACTIVITY BY AN OPTIMIZED AND VALIDATED IN VITRO MICROSCALE METHOD

Metabolic disorders, including hyperglycemia, characterize type-2 diabetes. One of the treatment methods used for postprandial hyperglycemia includes using potential therapeutic agents to inhibit α-amylase activity. This study utilized fractional design and the simplex method to optimize in vitro mi...

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Bibliographic Details
Main Authors: Graciela Granados Guzmán, Blanca Alicia Alanís Garza, Rocío Castro Ríos, Noemí Waksman Minsky, Ricardo Salazar Aranda
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2022-12-01
Series:Química Nova
Subjects:
optimization of enzyme method
validation of enzyme method
α-amylase activity
design of experiments.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901146&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901146&tlng=en

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