Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience
Introduction: Diffuse large B-cell lymphoma can be cured in 60% – 70% of patients. Autologous stem cell transplantation is the standard treatment for relapsed disease. This high-intensity treatment after first complete remission in patients with high International Prognostic Index remains controver...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2016-03-01
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| Series: | Acta Médica Portuguesa |
| Subjects: | |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6617 |
| _version_ | 1811242579872710656 |
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| author | Margarida Dantas Brito Fernando Campilho Rosa Branca Carlos Vaz Susana Roncon António Campos |
| author_facet | Margarida Dantas Brito Fernando Campilho Rosa Branca Carlos Vaz Susana Roncon António Campos |
| author_sort | Margarida Dantas Brito |
| collection | DOAJ |
| description |
Introduction: Diffuse large B-cell lymphoma can be cured in 60% – 70% of patients. Autologous stem cell transplantation is the standard treatment for relapsed disease. This high-intensity treatment after first complete remission in patients with high International Prognostic Index remains controversial and was performed in our department during some years.
Material and Methods: Retrospective study, review of clinical records.
Results: This study evaluates the outcome of 113 patients transplanted between 1992 and 2012. Considering status before transplantation patients were divided in groups: a) first complete remission after 1 line of chemotherapy (n = 64); b) first complete remission after ≥ two chemotherapy lines (n = 15); c) second complete remission (n = 15); d) more advanced diseased (n = 19). Chemotherapy used in first line therapy was mainly R-CHOP (n = 71) and CHOP (n = 28). The median follow-up of patients still alive was 34 months (1 - 221). At five years, overall survival was 73% (± 5) and disease free survival was 75% (± 5).
Conclusion: Conventional chemotherapy followed by autologous stem cell transplant is a safe and efficient option for selected patients. In our series 70% high-risk patients were free from disease with this strategy.
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| first_indexed | 2024-04-12T13:53:13Z |
| format | Article |
| id | doaj.art-a0ea8e9863574008a11db95fb281d64c |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:53:13Z |
| publishDate | 2016-03-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-a0ea8e9863574008a11db95fb281d64c2022-12-22T03:30:26ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582016-03-0129310.20344/amp.6617Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center ExperienceMargarida Dantas Brito0Fernando Campilho1Rosa Branca2Carlos Vaz3Susana Roncon4António Campos5Bone Marrow Transplantation Service. Instituto Português de Oncologia do Porto. Porto.Bone Marrow Transplantation Service. Instituto Português de Oncologia do Porto. Porto.Bone Marrow Transplantation Service. Instituto Português de Oncologia do Porto. Porto.Bone Marrow Transplantation Service. Instituto Português de Oncologia do Porto. Porto.Celular Therapy Service. Instituto Português de Oncologia do Porto. Porto.Bone Marrow Transplantation Service. Instituto Português de Oncologia do Porto. Porto. Introduction: Diffuse large B-cell lymphoma can be cured in 60% – 70% of patients. Autologous stem cell transplantation is the standard treatment for relapsed disease. This high-intensity treatment after first complete remission in patients with high International Prognostic Index remains controversial and was performed in our department during some years. Material and Methods: Retrospective study, review of clinical records. Results: This study evaluates the outcome of 113 patients transplanted between 1992 and 2012. Considering status before transplantation patients were divided in groups: a) first complete remission after 1 line of chemotherapy (n = 64); b) first complete remission after ≥ two chemotherapy lines (n = 15); c) second complete remission (n = 15); d) more advanced diseased (n = 19). Chemotherapy used in first line therapy was mainly R-CHOP (n = 71) and CHOP (n = 28). The median follow-up of patients still alive was 34 months (1 - 221). At five years, overall survival was 73% (± 5) and disease free survival was 75% (± 5). Conclusion: Conventional chemotherapy followed by autologous stem cell transplant is a safe and efficient option for selected patients. In our series 70% high-risk patients were free from disease with this strategy. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6617Hematopoietic Stem Cell TransplantationLymphomaLarge B-CellDiffuseTransplantationAutologous. |
| spellingShingle | Margarida Dantas Brito Fernando Campilho Rosa Branca Carlos Vaz Susana Roncon António Campos Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience Acta Médica Portuguesa Hematopoietic Stem Cell Transplantation Lymphoma Large B-Cell Diffuse Transplantation Autologous. |
| title | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience |
| title_full | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience |
| title_fullStr | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience |
| title_full_unstemmed | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience |
| title_short | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience |
| title_sort | twenty years of autologous stem cell transplantation in diffuse large b cell lymphoma a single portuguese center experience |
| topic | Hematopoietic Stem Cell Transplantation Lymphoma Large B-Cell Diffuse Transplantation Autologous. |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6617 |
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